PDB
8ZYT
Resolution
2.7 Å
Released
April 9, 2025
Receptor
NTS1
Class
A
Species
Homo sapiens
Ligands
Function
SBI-553
Allosteric agonist
NTS8–13
Agonist
Reference
—
SBI-553 NTS8–13

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Ligand Amino Acid Generic Number Segment Interaction Type
SBI-553 V101 2.39x39 TM2 Van der Waals
SBI-553 H102 2.40x40 TM2 Van der Waals
SBI-553 L105 2.43x43 TM2 Van der Waals
NTS8–13 F127 2.65x64 TM2 Van der Waals
NTS8–13 Y145 3.29x29 TM3 polar (hydrogen bond)
SBI-553 V159 3.43x43 TM3 Van der Waals
SBI-553 L162 3.46x46 TM3 hydrophobic
SBI-553 S163 3.47x47 TM3 Van der Waals
SBI-553 R166 3.50x50 TM3 hydrophobic
SBI-553 L170 3.54x54 TM3 hydrophobic
NTS8–13 C224 45.50x50 ECL2 Van der Waals
NTS8–13 P226 45.52x52 ECL2 hydrophobic
SBI-553 L305 6.37x37 TM6 hydrophobic
SBI-553 V308 6.40x40 TM6 hydrophobic
NTS8–13 R322 6.54x54 TM6 Van der Waals
NTS8–13 F326 6.58x58 TM6 hydrophobic
NTS8–13 W334 ECL3 Van der Waals
NTS8–13 Y339 7.28x27 TM7 Van der Waals
SBI-553 L363 7.52x52 TM7 hydrophobic
SBI-553 Y364 7.53x53 TM7 hydrophobic
SBI-553 V367 7.56x56 TM7 Van der Waals
SBI-553 S368 ICL4 Van der Waals
SBI-553 F371 8.50x50 H8 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 K S L Q ICL1ECL1 H H P W A F ECL1ICL2 P F K A K T L M ICL2ECL2 G E Q N R S A D G Q H A G G L V C T P T I ECL2ICL3 Q V C T V G G E H S T F S M A I E ICL3ECL3 S D E Q W ECL3N-term M R L N S S A P G T P G T P A A D P F Q R A Q A G L E E A L L A P G F G N A S G N A S E R V L A A P S S E L D V N T N-termC-term P V W R R R R K R P A F S R K A D S V S S N H T L S S N A T R E T L Y C-term D I Y S K V L V T A V Y L A L F V V G T V G N T V T A F T L A R K S L Q S T V H Y H L G S L A L S D L L T L L L A M P V E L Y N F I W V G D A G C R G Y Y F L R D A C T Y A T A L N V A S L S V E R Y L A I C H S R S R T K K F I S A I W L A S A L L A V P M L F T M H T A T V K V V I Q V N T F M S F I F P M V V I S V L N T I I A N K L T V M V R Q A A E Q G P G R V Q A L R H G V R V L R A V V I A F V V C W L P Y H V R R L M F C Y I T P F L Y D F Y H Y F Y M V T N A L F Y V S S T I N P I L Y N L V S A N F L A L C F R H I T L A C
Helix box plot — Download: PNG | SVG T N G V T G V V F L A L Y V A T V L V K 1 G S L A L S D L L T L L L A M P V E L Y N 2 S A V N L A T A Y T C A D R L F Y Y G R 3 T K K F I S A I W L A S A L L A V P M 4 N L V S I V V M P F I F S M F T N V Q I V 5 R A V V I A F V V C W L P Y H V R R L M 6 I P N I T S S V Y F L A N T V M Y F Y 7

GPCRdb(A)
GPCRdb(A)
NTS1 receptor
TM2
2x39 2.39x39 V101
2x40 2.40x40 H102
2x43 2.43x43 L105
2x64 2.65x64 F127
TM3
3x29 3.29x29 Y145
3x43 3.43x43 V159
3x46 3.46x46 L162
3x47 3.47x47 S163
3x50 3.50x50 R166
3x54 3.54x54 I170
ECL2
45x50 45.50x50 C224
45x52 45.52x52 P226
TM6
6x37 6.37x37 L305
6x40 6.40x40 V308
6x54 6.54x54 R322
6x58 6.58x58 F326
TM7
7x27 7.28x27 Y339
7x52 7.52x52 L363
7x53 7.53x53 Y364
7x56 7.56x56 V367
H8
8x50 8.50x50 F371