Structure information

β2-adrenoceptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

9CHX

SPECIES

Homo sapiens

RESOLUTION

3.500

PREFERRED CHAIN

A

REFERENCE

10.1073/PNAS.2414544121

PUBLICATION DATE

Nov. 13, 2024
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Ligand Interaction Browser

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LigandAmino AcidGeneric NumberSegmentInteraction Type
Ligand
Amino Acid
Generic Number
Segment
Interaction Type
Ligand
Amino Acid
Generic Number
Segment
Interaction Type
Carazolol D113 3.32x32 TM3 polar (charge-assisted hydrogen bond)
Carazolol V114 3.33x33 TM3 hydrophobic
Carazolol V117 3.36x36 TM3 Van der Waals
Carazolol V117 3.36x36 TM3 hydrophobic
Carazolol F193 45.52x52 ECL2 Van der Waals
Carazolol F193 45.52x52 ECL2 hydrophobic
Carazolol T195 ECL2 Van der Waals
Carazolol A200 5.39x40 TM5 hydrophobic
Carazolol S203 5.42x43 TM5 polar (hydrogen bond)
Carazolol S203 5.42x43 TM5 Van der Waals
Carazolol W409 ICL3 Van der Waals
Carazolol W409 ICL3 hydrophobic
Carazolol F412 ICL3 hydrophobic
Carazolol F412 ICL3 Van der Waals
Carazolol F413 ICL3 aromatic (edge-to-face)
Carazolol F413 ICL3 Van der Waals
Carazolol N416 6.55x55 TM6 Van der Waals
Carazolol N435 7.39x38 TM7 polar (hydrogen bond)
Carazolol N435 7.39x38 TM7 polar (hydrogen bond)
LigandAmino AcidGeneric NumberSegmentInteraction Type
Showing 1 to 19 of 19 entries

Ligands

Carazolol

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Residue Diagrams

V N G F V I A L V I L S M V I G M G V V 1 T S L A C A D L V M G A L V V P F G A A H 2 V C L T E I S A T V C L V D I S T W F E 3 A R V I I L M V W I V S G L T S F L P I 4 Y V F V M I V L P V Y F S V I S S A I A Y 5 G I I M G T F T L C W L P F F I V N I V 6 L P N F G S N V Y G I W N L L I Y V E 7
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ICL1 ECL1 ICL2 ECL2 ICL3 ECL3 N-term C-term Q E R D E V W V V G M G I V M S L I V L A I V F G N V L V I T A I A K F T V T N Y F I T S L A C A D L V M G L A V V P F G A A H I L M K G N F W C E F W T S I D V L C V T A S I E T L C V I A V D R Y F A I T S T K N K A R V I I L M V W I V S G L T S F L P I Q M H N Q A Y A I A S S I V S F Y V P L V I M V F V Y S R V F Q E A K R Q L Q K I D K S E S K F C L K E H K A L K T L G I I M G T F T L C W L P F F I V N I V H V I Q R K E V Y I L L N W I G Y V N S G F N P L I Y C R S P D F Q E F R I A L L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
β2-adrenoceptor
TM3
3x32 3.32x32 D113
3x33 3.33x33 V114
3x36 3.36x36 V117
ECL2
45x52 45.52x52 F193
TM5
5x40 5.39x40 A200
5x43 5.42x43 S203
TM6
6x55 6.55x55 N293
TM7
7x38 7.39x38 N312