PDB
9KUW
Resolution
3.5 Å
Released
Sept. 17, 2025
Receptor
apelin
Class
A
Species
Homo sapiens
Ligand
cmpd644
Function
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
cmpd644 W85 2.60x60 TM2 aromatic (face-to-edge)
cmpd644 I109 3.32x32 TM3 hydrophobic
cmpd644 F110 3.33x33 TM3 aromatic (edge-to-face)
cmpd644 R168 ECL2 polar (charge-assisted hydrogen bond)
cmpd644 Y264 6.51x51 TM6 aromatic (face-to-edge)
cmpd644 Y264 6.51x51 TM6 Van der Waals
cmpd644 Y271 6.58x58 TM6 aromatic (face-to-edge)
cmpd644 Y271 6.58x58 TM6 Van der Waals
cmpd644 M288 7.32x31 TM7 Van der Waals
cmpd644 F291 7.35x34 TM7 hydrophobic
cmpd644 F291 7.35x34 TM7 Van der Waals
cmpd644 T295 7.39x38 TM7 Van der Waals
cmpd644 Y299 7.43x42 TM7 Van der Waals
cmpd644 Y299 7.43x42 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 S R E K R ICL1ECL1 Y D W P F ECL1ICL2 P V A N A R L R ICL2ECL2 T T G D L E N T T K V Q C Y M D Y S M V A T V S ECL2ICL3 R K E ICL3ECL3 L H W ECL3N-term M E E G G D F D N Y Y G A D N Q S E C E Y T D W K S S G N-termC-term Q S R C A G T S H S S S G E K S A S Y S S G H S Q G P G P N M G K G G E Q M H E K S I P Y S Q E T L V V D C-term A L I P A I Y M L V F L L G T T G N G L V L W T V F R S R S A D I F I A S L A V A D L T F V V T L P L W A T Y T Y R D G T F F C K L S S Y L I F V N M Y A S V F C L T G L S F D R Y L A I V R L R V S G A V A T A V L W V L A A L L A M P V M V L R S E W A W E V G L G V S S T T V G F V V P F T I M L T C Y F F I A Q T I A G H F R I E G L R K R R R L L S I I V V L V V T F A L C W M P Y H L V K T L Y M L G S L P C D F D L F L M N I F P Y C T C I S Y V N S C L N P F L Y A F F D P R C T S G F R Q A M L C C
Helix box plot — Download: PNG | SVG G N G T T G L L F V L M Y I A P I L A 1 A S L A V A D L T F V V T L P L W A T Y 2 G T L C F V S A Y M N V F I L Y S S L K 3 G A V A T A V L W V L A A L L A M P V 4 Y C T L M I T F P V V F G V T T S S V G L 5 V V L V V T F A L C W M P Y H L V K T L 6 F P N L C S N V Y S I C T C Y P F I N 7

GPCRdb(A)
GPCRdb(A)
apelin receptor
TM2
2x60 2.60x60 W85
TM3
3x32 3.32x32 I109
3x33 3.33x33 F110
TM6
6x51 6.51x51 Y264
6x58 6.58x58 Y271
TM7
7x31 7.32x31 M288
7x34 7.35x34 F291
7x38 7.39x38 T295
7x42 7.43x42 Y299