PDB
9L60
Resolution
2.9 Å
Released
Dec. 31, 2025
Receptor
κ
Class
A
Species
Homo sapiens
Ligands
MPAM-15
Dynorphin A13
Function
PAM
Agonist
Reference
—
MPAM-15 Dynorphin A13

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
MPAM-15 L107 2.52x52 TM2 hydrophobic
Dynorphin A13 Y119 2.64x64 TM2 Van der Waals
Dynorphin A13 Y119 2.64x64 TM2 polar (hydrogen bond with backbone)
Dynorphin A13 N122 2.67x67 TM2 polar (hydrogen bond)
Dynorphin A13 V134 3.28x28 TM3 hydrophobic
Dynorphin A13 V134 3.28x28 TM3 Van der Waals
Dynorphin A13 I135 3.29x29 TM3 Van der Waals
Dynorphin A13 I135 3.29x29 TM3 hydrophobic
MPAM-15 I137 3.31x31 TM3 hydrophobic
Dynorphin A13 D138 3.32x32 TM3 Van der Waals
Dynorphin A13 Y139 3.33x33 TM3 hydrophobic
Dynorphin A13 Y139 3.33x33 TM3 Van der Waals
MPAM-15 Y140 3.34x34 TM3 hydrophobic
MPAM-15 N141 3.35x35 TM3 polar (hydrogen bond)
MPAM-15 N141 3.35x35 TM3 Van der Waals
Dynorphin A13 M142 3.36x36 TM3 Van der Waals
MPAM-15 W183 4.50x50 TM4 Van der Waals
MPAM-15 W183 4.50x50 TM4 hydrophobic
MPAM-15 S187 4.54x54 TM4 Van der Waals
MPAM-15 G190 4.57x57 TM4 Van der Waals
MPAM-15 I191 4.58x58 TM4 Van der Waals
MPAM-15 I191 4.58x58 TM4 hydrophobic
MPAM-15 I194 4.61x61 TM4 Van der Waals
Dynorphin A13 K200 ECL2 polar (charge-assisted hydrogen bond)
Dynorphin A13 E209 ECL2 Van der Waals
Dynorphin A13 C210 45.50x50 ECL2 Van der Waals
Dynorphin A13 S211 45.51x51 ECL2 Van der Waals
Dynorphin A13 Y219 5.31x32 TM5 polar (hydrogen bond)
Dynorphin A13 K227 5.39x40 TM5 Van der Waals
Dynorphin A13 V230 5.42x43 TM5 hydrophobic
Dynorphin A13 V230 5.42x43 TM5 Van der Waals
Dynorphin A13 I290 6.51x51 TM6 Van der Waals
Dynorphin A13 I294 6.55x55 TM6 hydrophobic
Dynorphin A13 I294 6.55x55 TM6 Van der Waals
Dynorphin A13 E297 6.58x58 TM6 polar (charge-assisted hydrogen bond)
Dynorphin A13 H304 ECL3 Van der Waals
Dynorphin A13 L309 7.32x31 TM7 hydrophobic
Dynorphin A13 L309 7.32x31 TM7 Van der Waals
Dynorphin A13 Y312 7.35x34 TM7 Van der Waals
Dynorphin A13 Y312 7.35x34 TM7 polar (hydrogen bond)
Dynorphin A13 Y313 7.36x35 TM7 polar (hydrogen bond)
Dynorphin A13 I316 7.39x38 TM7 hydrophobic
Dynorphin A13 I316 7.39x38 TM7 Van der Waals
Dynorphin A13 Y320 7.43x42 TM7 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 S W P F ECL1ICL2 P V K A L D F R ICL2ECL2 G T K V R E D V D V I E C S L Q F P D D ECL2ICL3 R L L S G ICL3ECL3 S T S H ECL3N-term M D S P I Q I F R G E P G P T C A P S A C L P P N S S A W F P G W A E P D S N G S A G S E D A Q L E P A H I S P N-termC-term P L K M R M E R Q S T S R V R N T V Q D P A Y L R D I D G M N K P V C-term A I P V I I T A V Y S V V F V V G L V G N S L V M F V I I R Y T A T N I Y I F N L A L A D A L V T T T M P F Q S T V Y L M N G D V L C K I V I S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H T P L K A K I I N I C I W L L S S S V G I S A I V L G D Y S W W D L F M K I C V F I F A F V I P V L I I I V C Y T L M I L R L K S V S R E K D R N L R R I T R L V L V V V A V F V V C W T P I H I F I L V E A L G S T A A L S S Y Y F C I A L G Y T N S S L N P I L Y A F L D E N F R D F K R C F C F
Helix box plot — Download: PNG | SVG S N G V L G V V F V V S Y V A T I I V P 1 F N L A L A D A L V T T T M P F Q S T V 2 M T L T F I S T F M N Y Y D I S I V I K 3 A K I I N I C I W L L S S S V G I S A I 4 Y C V I I I L V P I V F A F I F V C I K M 5 L V V V A V F V V C W T P I H I F I L V 6 I P N L S S N T Y G L A I C F Y Y S S 7

GPCRdb(A)
GPCRdb(A)
κ receptor
TM2
2x52 2.52x52 L107
2x64 2.64x64 Y119
2x67 2.67x67 N122
TM3
3x28 3.28x28 V134
3x29 3.29x29 I135
3x31 3.31x31 I137
3x32 3.32x32 D138
3x33 3.33x33 Y139
3x34 3.34x34 Y140
3x35 3.35x35 N141
3x36 3.36x36 M142
TM4
4x50 4.50x50 W183
4x54 4.54x54 S187
4x57 4.57x57 G190
4x58 4.58x58 I191
4x61 4.61x61 I194
ECL2
45x50 45.50x50 C210
45x51 45.51x51 S211
TM5
5x32 5.31x32 Y219
5x40 5.39x40 K227
5x43 5.42x43 V230
TM6
6x51 6.51x51 I290
6x55 6.55x55 I294
6x58 6.58x58 E297
TM7
7x31 7.32x31 L309
7x34 7.35x34 Y312
7x35 7.36x35 Y313
7x38 7.39x38 I316
7x42 7.43x42 Y320