PDB
9L84
Resolution
3.2 Å
Released
Dec. 31, 2025
Receptor
β1
Class
A
Species
Homo sapiens
Ligands
Function
(-)-adrenaline
Agonist
ATAZANAVIR
Ago-PAM
Reference
10.1016/J.CELL.2025.12.023
(-)-adrenaline ATAZANAVIR

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
(-)-adrenaline D138 3.32x32 TM3 polar (hydrogen bond)
(-)-adrenaline D138 3.32x32 TM3 polar (charge-charge)
(-)-adrenaline V139 3.33x33 TM3 Van der Waals
(-)-adrenaline V142 3.36x36 TM3 hydrophobic
(-)-adrenaline F218 45.52x52 ECL2 aromatic (pi-cation)
(-)-adrenaline S228 5.42x43 TM5 polar (hydrogen bond)
(-)-adrenaline S232 5.46x461 TM5 Van der Waals
ATAZANAVIR K324 6.35x35 TM6 Van der Waals
ATAZANAVIR I328 6.39x39 TM6 hydrophobic
ATAZANAVIR G331 6.42x42 TM6 Van der Waals
ATAZANAVIR V332 6.43x43 TM6 hydrophobic
(-)-adrenaline F340 6.51x51 TM6 hydrophobic
(-)-adrenaline F340 6.51x51 TM6 aromatic (edge-to-face)
(-)-adrenaline F341 6.52x52 TM6 hydrophobic
(-)-adrenaline F341 6.52x52 TM6 aromatic (edge-to-face)
(-)-adrenaline N344 6.55x55 TM6 Van der Waals
(-)-adrenaline N363 7.39x38 TM7 polar (hydrogen bond)
(-)-adrenaline Y367 7.43x42 TM7 Van der Waals
ATAZANAVIR F372 7.48x48 TM7 aromatic (edge-to-face)
ATAZANAVIR I375 7.51x51 TM7 hydrophobic
ATAZANAVIR I376 7.52x52 TM7 Van der Waals
ATAZANAVIR C378 7.54x54 TM7 Van der Waals
ATAZANAVIR R379 7.55x55 TM7 Van der Waals
ATAZANAVIR R384 8.51x51 H8 Van der Waals
ATAZANAVIR F387 8.54x54 H8 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 P R L Q ICL1ECL1 R W E Y ECL1ICL2 P F R Y Q S L L ICL2ECL2 W W R A E S D E A R R C Y N D P K C C D F V T ECL2ICL3 C E R R F L G G P A R P P S P S P S P V P A P A P P P G P P R P A A A A A T A P L A N G R A G K R R P S ICL3ECL3 R E L V ECL3N-term M G A G V L V L G A S E P G N L S S A A P L P D G A A T A A R L L V P A S P P A S L L P P A S E S N-termC-term C A R R A A R R R H A T H G D R P R A S G C L A R P G P P P S P G A A S D D D D D D V V G A T P P A R L L E P W A G C N G G A A A D S D S S L D E P C R P G F A S E S K V C-term P E P L S Q Q W T A G M G L L M A L I V L L I V A G N V L V I V A I A K T T L T N L F I M S L A S A D L V M G L L V V P F G A T I V V W G G S F F C E L W T S V D V L C V T A S I E T L C V I A L D R Y L A I T S T R A R A R G L V C T V W A I S A L V S F L P I L M H N R A Y A I A S S V V S F Y V P L C I M A F V Y L R V F R E A Q K Q V K K I D S R L V A L R E Q K A L K T L G I I M G V F T L C W L P F F L A N V V K A F H P D R L F V F F N W L G Y A N S A F N P I I Y C R S P D F Q R F R K A L L C
Helix box plot — Download: PNG | SVG V N G A V I L L V I L A M L L G M G A T 1 M S L A S A D L V M G L L V V P F G A T I 2 V C L T E I S A T V C L V D V S T W L E 3 A R G L V C T V W A I S A L V S F L P I 4 Y V F A M I C L P V Y F S V V S S A I A Y 5 G I I M G V F T L C W L P F F L A N V V 6 I P N F A S N A Y G L W N F F V F L R 7

GPCRdb(A)
GPCRdb(A)
β1-adrenoceptor
TM3
3x32 3.32x32 D138
3x33 3.33x33 V139
3x36 3.36x36 V142
ECL2
45x52 45.52x52 F218
TM5
5x43 5.42x43 S228
5x461 5.46x461 S232
TM6
6x35 6.35x35 K324
6x39 6.39x39 I328
6x42 6.42x42 G331
6x43 6.43x43 V332
6x51 6.51x51 F340
6x52 6.52x52 F341
6x55 6.55x55 N344
TM7
7x38 7.39x38 N363
7x42 7.43x42 Y367
7x48 7.48x48 F372
7x51 7.51x51 I375
7x52 7.52x52 I376
7x54 7.54x54 C378
7x55 7.55x55 R379
H8
8x51 8.51x51 R384
8x54 8.54x54 F387