PDB
9LWC
Resolution
2.9 Å
Released
Feb. 18, 2026
Receptor
D1
Class
A
Species
Homo sapiens
Ligand
(-)-adrenaline
Function
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
(-)-adrenaline D103 3.32x32 TM3 polar (charge-assisted hydrogen bond)
(-)-adrenaline I104 3.33x33 TM3 hydrophobic
(-)-adrenaline I104 3.33x33 TM3 Van der Waals
(-)-adrenaline V107 3.36x36 TM3 Van der Waals
(-)-adrenaline V107 3.36x36 TM3 hydrophobic
(-)-adrenaline L190 ECL2 Van der Waals
(-)-adrenaline S198 5.42x43 TM5 Van der Waals
(-)-adrenaline S198 5.42x43 TM5 polar (hydrogen bond)
(-)-adrenaline S198 5.42x43 TM5 polar (hydrogen bond with backbone)
(-)-adrenaline S199 5.43x44 TM5 Van der Waals
(-)-adrenaline S202 5.46x461 TM5 polar (hydrogen bond)
(-)-adrenaline S202 5.46x461 TM5 Van der Waals
(-)-adrenaline F288 6.51x51 TM6 Van der Waals
(-)-adrenaline F288 6.51x51 TM6 hydrophobic
(-)-adrenaline F289 6.52x52 TM6 aromatic (edge-to-face)
(-)-adrenaline F289 6.52x52 TM6 Van der Waals
(-)-adrenaline N292 6.55x55 TM6 polar (hydrogen bond)
(-)-adrenaline N292 6.55x55 TM6 Van der Waals
(-)-adrenaline N317 7.39x38 TM7 Van der Waals
(-)-adrenaline Y321 7.43x42 TM7 polar (hydrogen bond)
(-)-adrenaline Y321 7.43x42 TM7 Van der Waals

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ICL1 R H L R S ICL1ECL1 F W P F ECL1ICL2 P F R Y E R K M ICL2ECL2 W H K A K P T S P S D G N A T S L A E T I D N C D S S L ECL2ICL3 T T T G N G K P V E C S Q P E S S F ICL3ECL3 G S G E T Q P F C I ECL3N-term M R T L N T S A M D G T G L V V E R D F N-termC-term C Y R L C P A T N N A I E T V S I N N N G A A M F S S H H E P R G S I S K E C N L V Y L I P H A V G S S E D L K K E E A A G I A R P L E K L S P A L S V I L D Y D T D V S L E K I Q P I T Q N G Q H P T C-term S V R I L T A C F L S L L I L S T L L G N T L V C A A V I R F K V T N F F V I S L A V S D L L V A V L V M P W K A V A E I A G G S F C N I W V A F D I M C S T A S I L N L C V I S V D R Y W A I S S T P K A A F I L I S V A W T L S V L I S F I P V Q L S S R T Y A I S S S V I S F Y I P V A I M I V T Y T R I Y R I A Q K Q I R R I A A L E R A A V H A K N C Q K M S F K R E T K V L K T L S V I M G V F V C C W L P F F I L N C I L P F C D S N T F D V F V W F G W A N S S L N P I I Y A F N A D F S T F R K A L L G
Helix box plot — Download: PNG | SVG T N G L L T S L I L L S L F C A T L I R 1 I S L A V S D L L V A L V V M P W K A V A 2 V C L N L I S A T S C M I D F A V W I N 3 A F I L I S V A W T L S V L I S F I P V 4 Y T V I M I A V P I Y F S I V S S S I A Y 5 S V I M G V F V C C W L P F F I L N C I 6 I P N L S S N A W G F W V F V D F T N 7

GPCRdb(A)
GPCRdb(A)
D1 receptor
TM3
3x32 3.32x32 D103
3x33 3.33x33 I104
3x36 3.36x36 S107
TM5
5x43 5.42x43 S198
5x44 5.43x44 S199
5x461 5.46x461 S202
TM6
6x51 6.51x51 F288
6x52 6.52x52 F289
6x55 6.55x55 N292
TM7
7x38 7.39x38 V317
7x42 7.43x42 W321