PDB
9P7Z
Resolution
2.1 Å
Released
March 25, 2026
Receptor
NTS1
Class
A
Species
Homo sapiens
Ligand
Function
NTS8–13
Agonist
Reference
10.1038/S41586-026-10120-7

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Ligand Amino Acid Generic Number Segment Interaction Type
NTS8–13 S52 N-term Van der Waals
NTS8–13 E53 N-term polar (hydrogen bond with backbone)
NTS8–13 L54 N-term polar (hydrogen bond with backbone)
NTS8–13 L54 N-term hydrophobic
NTS8–13 D55 N-term Van der Waals
NTS8–13 V56 N-term Van der Waals
NTS8–13 N57 N-term Van der Waals
NTS8–13 F127 2.65x64 TM2 hydrophobic
NTS8–13 H131 ECL1 Van der Waals
NTS8–13 H132 ECL1 Van der Waals
NTS8–13 Y145 3.29x29 TM3 polar (hydrogen bond)
NTS8–13 V223 ECL2 hydrophobic
NTS8–13 C224 45.50x50 ECL2 Van der Waals
NTS8–13 T225 45.51x51 ECL2 polar (hydrogen bond)
NTS8–13 I237 5.39x40 TM5 Van der Waals
NTS8–13 R322 6.54x54 TM6 polar (charge-charge)
NTS8–13 R322 6.54x54 TM6 polar (hydrogen bond)
NTS8–13 R323 6.55x55 TM6 hydrophobic
NTS8–13 R323 6.55x55 TM6 polar (charge-charge)
NTS8–13 F326 6.58x58 TM6 aromatic (pi-cation)
NTS8–13 F326 6.58x58 TM6 polar (hydrogen bond with backbone)
NTS8–13 F326 6.58x58 TM6 hydrophobic
NTS8–13 C327 6.59x59 TM6 polar (hydrogen bond with backbone)
NTS8–13 Y328 6.60x60 TM6 Van der Waals
NTS8–13 I329 ECL3 Van der Waals
NTS8–13 D331 ECL3 polar (charge-charge)
NTS8–13 W334 ECL3 hydrophobic
NTS8–13 Y339 7.28x27 TM7 hydrophobic
NTS8–13 Y342 7.31x30 TM7 polar (hydrogen bond)
NTS8–13 Y342 7.31x30 TM7 hydrophobic
NTS8–13 Y346 7.35x34 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 K S L Q ICL1ECL1 H H P W A F ECL1ICL2 P F K A K T L M ICL2ECL2 G E Q N R S A D G Q H A G G L V C T P T I ECL2ICL3 Q V C T V G G E H S T F S M A I E ICL3ECL3 S D E Q W ECL3N-term M R L N S S A P G T P G T P A A D P F Q R A Q A G L E E A L L A P G F G N A S G N A S E R V L A A P S S E L D V N T N-termC-term P V W R R R R K R P A F S R K A D S V S S N H T L S S N A T R E T L Y C-term D I Y S K V L V T A V Y L A L F V V G T V G N T V T A F T L A R K S L Q S T V H Y H L G S L A L S D L L T L L L A M P V E L Y N F I W V G D A G C R G Y Y F L R D A C T Y A T A L N V A S L S V E R Y L A I C H S R S R T K K F I S A I W L A S A L L A V P M L F T M H T A T V K V V I Q V N T F M S F I F P M V V I S V L N T I I A N K L T V M V R Q A A E Q G P G R V Q A L R H G V R V L R A V V I A F V V C W L P Y H V R R L M F C Y I T P F L Y D F Y H Y F Y M V T N A L F Y V S S T I N P I L Y N L V S A N F L A L C F R H I T L A C
Helix box plot — Download: PNG | SVG T N G V T G V V F L A L Y V A T V L V K 1 G S L A L S D L L T L L L A M P V E L Y N 2 S A V N L A T A Y T C A D R L F Y Y G R 3 T K K F I S A I W L A S A L L A V P M 4 N L V S I V V M P F I F S M F T N V Q I V 5 R A V V I A F V V C W L P Y H V R R L M 6 I P N I T S S V Y F L A N T V M Y F Y 7

GPCRdb(A)
GPCRdb(A)
NTS1 receptor
TM2
2x64 2.65x64 F127
TM3
3x29 3.29x29 Y145
ECL2
45x50 45.50x50 C224
45x51 45.51x51 T225
TM5
5x40 5.39x40 I237
TM6
6x54 6.54x54 R322
6x55 6.55x55 R323
6x58 6.58x58 F326
6x59 6.59x59 C327
6x60 6.60x60 Y328
TM7
7x27 7.28x27 Y339
7x30 7.31x30 Y342
7x34 7.35x34 Y346