PDB
9P81
Resolution
2.6 Å
Released
March 25, 2026
Receptor
NTS1
Class
A
Species
Homo sapiens
Ligand
NTS8–13
Function
Agonist
Reference
10.1038/S41586-026-10120-7

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Ligand Amino Acid Generic Number Segment Interaction Type
NTS8–13 S52 N-term polar (hydrogen bond with backbone)
NTS8–13 S52 N-term Van der Waals
NTS8–13 E53 N-term Van der Waals
NTS8–13 E53 N-term polar (hydrogen bond with backbone)
NTS8–13 L54 N-term Van der Waals
NTS8–13 L54 N-term polar (hydrogen bond with backbone)
NTS8–13 D55 N-term Van der Waals
NTS8–13 D55 N-term polar (hydrogen bond with backbone)
NTS8–13 F127 2.65x64 TM2 Van der Waals
NTS8–13 F127 2.65x64 TM2 hydrophobic
NTS8–13 H131 ECL1 Van der Waals
NTS8–13 H132 ECL1 Van der Waals
NTS8–13 Y145 3.29x29 TM3 polar (hydrogen bond)
NTS8–13 Y145 3.29x29 TM3 Van der Waals
NTS8–13 V223 ECL2 Van der Waals
NTS8–13 V223 ECL2 hydrophobic
NTS8–13 C224 45.50x50 ECL2 Van der Waals
NTS8–13 C224 45.50x50 ECL2 polar (hydrogen bond with backbone)
NTS8–13 T225 45.51x51 ECL2 Van der Waals
NTS8–13 R322 6.54x54 TM6 polar (charge-assisted hydrogen bond)
NTS8–13 R323 6.55x55 TM6 Van der Waals
NTS8–13 F326 6.58x58 TM6 Van der Waals
NTS8–13 F326 6.58x58 TM6 polar (hydrogen bond with backbone)
NTS8–13 C327 6.59x59 TM6 Van der Waals
NTS8–13 Y328 ECL3 Van der Waals
NTS8–13 Y328 ECL3 polar (hydrogen bond with backbone)
NTS8–13 I329 ECL3 Van der Waals
NTS8–13 I329 ECL3 polar (hydrogen bond with backbone)
NTS8–13 S330 ECL3 Van der Waals
NTS8–13 W334 ECL3 Van der Waals
NTS8–13 W334 ECL3 hydrophobic
NTS8–13 Y339 7.28x27 TM7 hydrophobic
NTS8–13 Y339 7.28x27 TM7 Van der Waals
NTS8–13 Y342 7.31x30 TM7 polar (hydrogen bond)
NTS8–13 Y342 7.31x30 TM7 Van der Waals
NTS8–13 Y346 7.35x34 TM7 Van der Waals
NTS8–13 Y346 7.35x34 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 K S L Q ICL1ECL1 H H P W A F ECL1ICL2 P F K A K T L M ICL2ECL2 G E Q N R S A D G Q H A G G L V C T P T I ECL2ICL3 Q V C T V G G E H S T F S M A I E ICL3ECL3 S D E Q W ECL3N-term M R L N S S A P G T P G T P A A D P F Q R A Q A G L E E A L L A P G F G N A S G N A S E R V L A A P S S E L D V N T N-termC-term P V W R R R R K R P A F S R K A D S V S S N H T L S S N A T R E T L Y C-term D I Y S K V L V T A V Y L A L F V V G T V G N T V T A F T L A R K S L Q S T V H Y H L G S L A L S D L L T L L L A M P V E L Y N F I W V G D A G C R G Y Y F L R D A C T Y A T A L N V A S L S V E R Y L A I C H S R S R T K K F I S A I W L A S A L L A V P M L F T M H T A T V K V V I Q V N T F M S F I F P M V V I S V L N T I I A N K L T V M V R Q A A E Q G P G R V Q A L R H G V R V L R A V V I A F V V C W L P Y H V R R L M F C Y I T P F L Y D F Y H Y F Y M V T N A L F Y V S S T I N P I L Y N L V S A N F L A L C F R H I T L A C
Helix box plot — Download: PNG | SVG T N G V T G V V F L A L Y V A T V L V K 1 G S L A L S D L L T L L L A M P V E L Y N 2 S A V N L A T A Y T C A D R L F Y Y G R 3 T K K F I S A I W L A S A L L A V P M 4 N L V S I V V M P F I F S M F T N V Q I V 5 R A V V I A F V V C W L P Y H V R R L M 6 I P N I T S S V Y F L A N T V M Y F Y 7

GPCRdb(A)
GPCRdb(A)
NTS1 receptor
TM2
2x64 2.65x64 F127
TM3
3x29 3.29x29 Y145
ECL2
45x50 45.50x50 C224
45x51 45.51x51 T225
TM6
6x54 6.54x54 R322
6x55 6.55x55 R323
6x58 6.58x58 F326
6x59 6.59x59 C327
TM7
7x27 7.28x27 Y339
7x30 7.31x30 Y342
7x34 7.35x34 Y346