PDB
9P86
Resolution
2.9 Å
Released
March 25, 2026
Receptor
NTS1
Class
A
Species
Homo sapiens
Ligand
NTS8–13
Function
Agonist
Reference
10.1038/S41586-026-10120-7

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Ligand Amino Acid Generic Number Segment Interaction Type
NTS8–13 L54 N-term Van der Waals
NTS8–13 L54 N-term polar (hydrogen bond with backbone)
NTS8–13 H131 ECL1 polar (hydrogen bond with backbone)
NTS8–13 H131 ECL1 Van der Waals
NTS8–13 Y145 3.29x29 TM3 Van der Waals
NTS8–13 Y145 3.29x29 TM3 polar (hydrogen bond)
NTS8–13 V223 ECL2 Van der Waals
NTS8–13 R322 6.54x54 TM6 polar (charge-assisted hydrogen bond)
NTS8–13 R323 6.55x55 TM6 Van der Waals
NTS8–13 F326 6.58x58 TM6 polar (hydrogen bond with backbone)
NTS8–13 F326 6.58x58 TM6 Van der Waals
NTS8–13 C327 6.59x59 TM6 polar (hydrogen bond with backbone)
NTS8–13 C327 6.59x59 TM6 Van der Waals
NTS8–13 I329 6.61x61 TM6 polar (hydrogen bond with backbone)
NTS8–13 I329 6.61x61 TM6 Van der Waals
NTS8–13 W334 ECL3 polar (hydrogen bond with backbone)
NTS8–13 W334 ECL3 Van der Waals
NTS8–13 T335 7.24x23 TM7 Van der Waals
NTS8–13 P336 7.25x24 TM7 Van der Waals
NTS8–13 Y339 7.28x27 TM7 hydrophobic
NTS8–13 Y339 7.28x27 TM7 Van der Waals
NTS8–13 Y342 7.31x30 TM7 polar (hydrogen bond)
NTS8–13 Y342 7.31x30 TM7 Van der Waals
NTS8–13 H343 7.32x31 TM7 Van der Waals
NTS8–13 Y346 7.35x34 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 K S L Q ICL1ECL1 H H P W A F ECL1ICL2 P F K A K T L M ICL2ECL2 G E Q N R S A D G Q H A G G L V C T P T I ECL2ICL3 Q V C T V G G E H S T F S M A I E ICL3ECL3 S D E Q W ECL3N-term M R L N S S A P G T P G T P A A D P F Q R A Q A G L E E A L L A P G F G N A S G N A S E R V L A A P S S E L D V N T N-termC-term P V W R R R R K R P A F S R K A D S V S S N H T L S S N A T R E T L Y C-term D I Y S K V L V T A V Y L A L F V V G T V G N T V T A F T L A R K S L Q S T V H Y H L G S L A L S D L L T L L L A M P V E L Y N F I W V G D A G C R G Y Y F L R D A C T Y A T A L N V A S L S V E R Y L A I C H S R S R T K K F I S A I W L A S A L L A V P M L F T M H T A T V K V V I Q V N T F M S F I F P M V V I S V L N T I I A N K L T V M V R Q A A E Q G P G R V Q A L R H G V R V L R A V V I A F V V C W L P Y H V R R L M F C Y I T P F L Y D F Y H Y F Y M V T N A L F Y V S S T I N P I L Y N L V S A N F L A L C F R H I T L A C
Helix box plot — Download: PNG | SVG T N G V T G V V F L A L Y V A T V L V K 1 G S L A L S D L L T L L L A M P V E L Y N 2 S A V N L A T A Y T C A D R L F Y Y G R 3 T K K F I S A I W L A S A L L A V P M 4 N L V S I V V M P F I F S M F T N V Q I V 5 R A V V I A F V V C W L P Y H V R R L M 6 I P N I T S S V Y F L A N T V M Y F Y 7

GPCRdb(A)
GPCRdb(A)
NTS1 receptor
TM3
3x29 3.29x29 Y145
TM6
6x54 6.54x54 R322
6x55 6.55x55 R323
6x58 6.58x58 F326
6x59 6.59x59 C327
6x61 6.61x61 I329
TM7
7x23 7.24x23 T335
7x24 7.25x24 P336
7x27 7.28x27 Y339
7x30 7.31x30 Y342
7x31 7.32x31 H343
7x34 7.35x34 Y346