PDB
9UYM
Resolution
3.5 Å
Released
Nov. 19, 2025
Receptor
chemerin 2
Class
A
Species
Homo sapiens
Ligand
Function
Chemerin
Agonist
Reference
10.1126/SCIENCE.ADT8794

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Ligand Amino Acid Generic Number Segment Interaction Type
Chemerin D20 N-term polar (hydrogen bond with backbone)
Chemerin Y21 N-term polar (hydrogen bond)
Chemerin Y21 N-term hydrophobic
Chemerin Y22 N-term hydrophobic
Chemerin Y22 N-term polar (hydrogen bond)
Chemerin Y22 N-term polar (hydrogen bond)
Chemerin S23 N-term Van der Waals
Chemerin L24 N-term hydrophobic
Chemerin E25 N-term hydrophobic
Chemerin E25 N-term polar (hydrogen bond with backbone)
Chemerin S26 N-term Van der Waals
Chemerin L28 N-term Van der Waals
Chemerin F86 2.53x53 TM2 hydrophobic
Chemerin Y93 2.60x60 TM2 aromatic (edge-to-face)
Chemerin Y93 2.60x60 TM2 hydrophobic
Chemerin Y96 2.63x63 TM2 Van der Waals
Chemerin F101 ECL1 hydrophobic
Chemerin S114 3.29x29 TM3 polar (hydrogen bond)
Chemerin A117 3.32x32 TM3 hydrophobic
Chemerin Q118 3.33x33 TM3 polar (hydrogen bond)
Chemerin M121 3.36x36 TM3 hydrophobic
Chemerin R176 ECL2 polar (hydrogen bond)
Chemerin R176 ECL2 polar (charge-charge)
Chemerin V179 ECL2 hydrophobic
Chemerin E180 ECL2 Van der Waals
Chemerin F181 ECL2 Van der Waals
Chemerin L186 ECL2 Van der Waals
Chemerin Y188 45.51x51 ECL2 hydrophobic
Chemerin N189 45.52x52 ECL2 Van der Waals
Chemerin F191 ECL2 Van der Waals
Chemerin K210 5.42x43 TM5 polar (charge-charge)
Chemerin Y262 6.51x51 TM6 Van der Waals
Chemerin E269 6.58x58 TM6 polar (hydrogen bond)
Chemerin M282 7.31x30 TM7 Van der Waals
Chemerin Q283 7.32x31 TM7 Van der Waals
Chemerin I286 7.35x34 TM7 hydrophobic
Chemerin T290 7.39x38 TM7 hydrophobic
Chemerin F294 7.43x42 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 K K ICL1ECL1 F H W P F ECL1ICL2 P V L S H R H R ICL2ECL2 D T V E F N N H T L C Y N N F Q K H D P D ECL2ICL3 I L I ICL3ECL3 H N S Y S ECL3N-term M E D L E E T L F E E F E N Y S Y D L D Y Y S L E S D L E E K V Q L N-termC-term A E I L K Y T L W E V S C S G T V S E Q L R N S E T K N L C L L E T A Q C-term G V V H W V S L V L Y C L A F V L G I P G N A I V I W F T G F K W T V T T L W F L N L A I A D F I F L L F L P L Y I S Y V A M N G I W L C K A N S F T A Q L N M F A S V F F L T V I S L D H Y I H L I H T L K N S L I V I I F I W L L A S L I G G P A L Y F R L T L I R H H V L T W V K F I I G Y L F P L L T M S I C Y L C L I F K V K K R S S S R H F W T I L V V V V A F V V C W T P Y H L F S I W E L T I H H H V M Q A G I P L S T G L A F L N S C L N P I L Y V L I S K K F R S F Q A R S V
Helix box plot — Download: PNG | SVG A N G P I G L V F A L C Y L V L S V W H 1 L N L A I A D F I F L L F L P L Y I S Y 2 V T L F F V S A F M N L Q A T F S N A K 3 S L I V I I F I W L L A S L I G G P A L 4 Y C I S M T L L P F L Y G I I F K V W T L 5 L V V V V A F V V C W T P Y H L F S I W 6 I P N L C S N L F A L G T S L P I G A 7

GPCRdb(A)
GPCRdb(A)
chemerin receptor 2
TM2
2x53 2.53x53 F86
2x60 2.60x60 Y93
2x63 2.63x63 Y96
TM3
3x29 3.29x29 S114
3x32 3.32x32 A117
3x33 3.33x33 Q118
3x36 3.36x36 M121
ECL2
45x51 45.51x51 Y188
45x52 45.52x52 N189
TM5
5x43 5.42x43 K210
TM6
6x51 6.51x51 Y262
6x58 6.58x58 E269
TM7
7x30 7.31x30 M282
7x31 7.32x31 Q283
7x34 7.35x34 I286
7x38 7.39x38 T290
7x42 7.43x42 F294