PDB
9WQL
Resolution
3.2 Å
Released
May 27, 2026
Receptor
mGlu5
Class
C
Species
Homo sapiens
Ligands
Function
CDPPB
PAM
L-glutamic acid
Agonist
Reference
10.1126/SCIADV.AEE0044
CDPPB L-glutamic acid

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Ligand Amino Acid Generic Number Segment Interaction Type
L-glutamic acid Y64 N-term polar (hydrogen bond)
L-glutamic acid R68 N-term polar (charge-charge)
L-glutamic acid W100 N-term hydrophobic
L-glutamic acid G150 N-term Van der Waals
L-glutamic acid S151 N-term Van der Waals
L-glutamic acid S152 N-term polar (hydrogen bond with backbone)
L-glutamic acid S152 N-term polar (hydrogen bond)
L-glutamic acid S173 N-term polar (hydrogen bond with backbone)
L-glutamic acid A174 N-term Van der Waals
L-glutamic acid T175 N-term polar (hydrogen bond)
L-glutamic acid T175 N-term polar (hydrogen bond with backbone)
L-glutamic acid Y223 N-term aromatic (pi-cation)
L-glutamic acid D305 N-term polar (hydrogen bond)
L-glutamic acid D305 N-term polar (charge-charge)
L-glutamic acid G306 N-term Van der Waals
L-glutamic acid R310 N-term polar (charge-charge)
L-glutamic acid K396 N-term polar (charge-charge)
L-glutamic acid K396 N-term polar (hydrogen bond)
CDPPB G624 2.45x45 TM2 Van der Waals
CDPPB I625 2.46x46 TM2 hydrophobic
CDPPB G628 2.49x49 TM2 Van der Waals
CDPPB S654 3.39x39 TM3 Van der Waals
CDPPB P655 3.40x40 TM3 hydrophobic
CDPPB S658 3.43x43 TM3 Van der Waals
CDPPB Y659 3.44x44 TM3 aromatic (edge-to-face)
CDPPB Y659 3.44x44 TM3 hydrophobic
CDPPB L744 5.44x44 TM5 hydrophobic
CDPPB G745 5.45x45 TM5 Van der Waals
CDPPB N747 5.47x47 TM5 Van der Waals
CDPPB G748 5.48x48 TM5 Van der Waals
CDPPB I751 5.51x51 TM5 hydrophobic
CDPPB T781 6.46x46 TM6 Van der Waals
CDPPB C782 6.47x47 TM6 Van der Waals
CDPPB W785 6.50x50 TM6 aromatic (face-to-face)
CDPPB W785 6.50x50 TM6 hydrophobic
CDPPB W785 6.50x50 TM6 aromatic (edge-to-face)
CDPPB F788 6.53x53 TM6 aromatic (edge-to-face)
CDPPB F788 6.53x53 TM6 hydrophobic
CDPPB M802 7.32x33 TM7 hydrophobic
CDPPB S805 7.35x36 TM7 Van der Waals
CDPPB V806 7.36x37 TM7 hydrophobic
CDPPB S809 7.39x40 TM7 Van der Waals
CDPPB A810 7.40x41 TM7 hydrophobic
CDPPB A813 7.43x44 TM7 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

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NGL is a WebGL based 3D viewer powered by MMTF.

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Snake plot — Download: PNG | SVG
ICL1 T R D P V V K S S ICL1ECL1 A K P ECL1ICL2 A G S K K K I C T K K P R F M ICL2ECL2 P P D I M H D Y P S I R E V Y L I C N T ECL2ICL3 R N V P A N F N ICL3ECL3 N ECL3N-term M V L L L I L S V L L L K E D V R G S A Q S S E R R V V A H M P G D I I I G A L F S V H H Q P T V D K V H E R K C G A V R E Q Y G I Q R V E A M L H T L E R I N S D P T L L P N I T L G C E I R D S C W H S A V A L E Q S I E F I R D S L I S S E E E E G L V R C V D G S S S S F R S K K P I V G V I G P G S S S V A I Q V Q N L L Q L F N I P Q I A Y S A T S M D L S D K T L F K Y F M R V V P S D A Q Q A R A M V D I V K R Y N W T Y V S A V H T E G N Y G E S G M E A F K D M S A K E G I C I A H S Y K I Y S N A G E Q S F D K L L K K L T S H L P K A R V V A C F C E G M T V R G L L M A M R R L G L A G E F L L L G S D G W A D R Y D V T D G Y Q R E A V G G I T I K L Q S P D V K W F D D Y Y L K L R P E T N H R N P W F Q E F W Q H R F Q C R L E G F P Q E N S K Y N K T C N S S L T L K T H H V Q D S K M G F V I N A I Y S M A Y G L H N M Q M S L C P G Y A G L C D A M K P I D G R K L L E S L M K T N F T G V S G D T I L F D E N G D S P G R Y E I M N F K E M G K D Y F D Y I N V G S W D N G E L K M D D D E V W S K K S N I I R S V C S E P C E K G Q I K V I R K G E V S C C W T C T P C K E N E Y V F D E Y T C K A C Q L G S W P T D D L T G C D L I P V Q Y L R W G D N-termC-term T V V R M H V G D G K S S S A A S R S S S L V N L W K R R G S S G E T L R Y K D R R L A Q H K S E I E C F T P K G S M G N G G R A T M S S S N G K S V T W A Q N E K S S R G Q H L W Q R L S I H I N K K E N P N Q T A V I K P F P K S T E S R G L G A G A G A G G S A G G V G A T G G A G C A G A G P G G P E S P D A G P K A L Y D V A E A E E H F P A P A R P R S P S P I S T L S H R A G S A S R T D D D V P S L H S E P V A R S S S S Q G S L M E Q I S S V V T R F T A N I S E L N S M M L S T A A P S P G V G A P L C S S Y L I P K E I Q L P T T M T T F A E I Q P L P A I E V T G G A Q P A A G A Q A A G D A A R E S P A A G P E A A A A K P D L E E L V A L T P P S P F R D S V D S G S T T P N S P V S E S A L C I P S S P K Y D T L I I R D Y T Q S S S S L C-term P E P I A A V V F A C L G L L A T L F V T V V F I I Y S R E L C Y I I L A G I C L G Y L C T F C L I K Q I Y C Y L Q R I G I G L S P A M S Y S A L V T K T N R I A R I L S A C A Q L V I A F I L I C I Q L G I I V A L F I M E T N L G V V T P L G Y N G L L I L S C T F Y A F K T E A K Y I A F T M Y T T C I I W L A F V P I Y F G S Y K I I T M C F S V S L S A T V A L G C M F V P K V Y I I L A K P E R A F T N V R S T S
Helix box plot — Download: PNG | SVG L T A L L G L C A F V V A A I P E P 1 Y I I L A G I C L G Y L C T F C L I 2 T V L A S Y S M A P S L G I G I R Q L Y 3 Q L V I A F I L I C I Q L G I I V A L F 4 A Y F T C S L I L L G N Y G L P T V V G 5 A F T M Y T T C I I W L A F V P I Y F G 6 G L A V T A S L S V S F C M T I I K Y 7

GPCRdb(A)
GPCRdb(C)
mGlu5 receptor
TM2
2x49 2.45x45 G624
2x50 2.46x46 I625
2x53 2.49x49 G628
TM3
3x35 3.39x39 S654
3x36 3.40x40 P655
3x39 3.43x43 S658
3x40 3.44x44 Y659
TM5
5x44 5.44x44 L744
5x45 5.45x45 G745
5x47 5.47x47 N747
5x48 5.48x48 G748
5x51 5.51x51 I751
TM6
6x44 6.46x46 T781
6x45 6.47x47 C782
6x48 6.50x50 W785
6x51 6.53x53 F788
TM7
7x38 7.32x33 M802
7x41 7.35x36 S805
7x42 7.36x37 V806
7x45 7.39x40 S809
7x46 7.40x41 A810
7x49 7.43x44 A813