PDB
9WQN
Resolution
3.7 Å
Released
May 27, 2026
Receptor
mGlu1
Class
C
Species
Homo sapiens
Ligands
L-glutamic acid
Ro0711401
Function
Agonist
PAM
Reference
—
L-glutamic acid Ro0711401

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Ligand Amino Acid Generic Number Segment Interaction Type
L-glutamic acid Y74 N-term polar (hydrogen bond)
L-glutamic acid Y74 N-term polar (hydrogen bond)
L-glutamic acid W110 N-term hydrophobic
L-glutamic acid W110 N-term Van der Waals
L-glutamic acid G163 N-term Van der Waals
L-glutamic acid S164 N-term Van der Waals
L-glutamic acid S165 N-term polar (hydrogen bond with backbone)
L-glutamic acid S165 N-term polar (hydrogen bond)
L-glutamic acid S165 N-term Van der Waals
L-glutamic acid S186 N-term polar (hydrogen bond with backbone)
L-glutamic acid S186 N-term polar (hydrogen bond)
L-glutamic acid S186 N-term Van der Waals
L-glutamic acid A187 N-term Van der Waals
L-glutamic acid T188 N-term polar (hydrogen bond with backbone)
L-glutamic acid T188 N-term Van der Waals
L-glutamic acid Y236 N-term hydrophobic
L-glutamic acid Y236 N-term Van der Waals
L-glutamic acid D318 N-term polar (hydrogen bond with backbone)
L-glutamic acid D318 N-term polar (charge-assisted hydrogen bond)
L-glutamic acid G319 N-term Van der Waals
L-glutamic acid K409 N-term polar (charge-assisted hydrogen bond)
Ro0711401 Y672 3.44x44 TM3 polar (hydrogen bond)
Ro0711401 Y672 3.44x44 TM3 Van der Waals
Ro0711401 L757 5.44x44 TM5 hydrophobic
Ro0711401 L757 5.44x44 TM5 Van der Waals
Ro0711401 N760 5.47x47 TM5 Van der Waals
Ro0711401 G761 5.48x48 TM5 Van der Waals
Ro0711401 I764 5.51x51 TM5 Van der Waals
Ro0711401 I764 5.51x51 TM5 hydrophobic
Ro0711401 T794 6.46x46 TM6 Van der Waals
Ro0711401 C795 6.47x47 TM6 Van der Waals
Ro0711401 W798 6.50x50 TM6 aromatic (edge-to-face)
Ro0711401 W798 6.50x50 TM6 Van der Waals
Ro0711401 F801 6.53x53 TM6 Van der Waals
Ro0711401 F801 6.53x53 TM6 aromatic (face-to-edge)
Ro0711401 A818 7.35x36 TM7 hydrophobic
Ro0711401 A818 7.35x36 TM7 Van der Waals
Ro0711401 V819 7.36x37 TM7 hydrophobic
Ro0711401 V819 7.36x37 TM7 Van der Waals
Ro0711401 S822 7.39x40 TM7 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

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NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 T R D P V V K S S ICL1ECL1 K P ECL1ICL2 A G S K K K I C T R K P R F M ICL2ECL2 P P M P I L S Y P S I K E V Y L I C N T ECL2ICL3 R N V P A N F N ICL3ECL3 N ECL3N-term M V G L L L F F F P A I F L E V S L L P R S P G R K V L L A G A S S Q R S V A R M D G D V I I G A L F S V H H Q P P A E K V P E R K C G E I R E Q Y G I Q R V E A M F H T L D K I N A D P V L L P N I T L G S E I R D S C W H S S V A L E Q S I E F I R D S L I S I R D E K D G I N R C L P D G Q S L P P G R T K K P I A G V I G P G S S S V A I Q V Q N L L Q L F D I P Q I A Y S A T S I D L S D K T L Y K Y F L R V V P S D T L Q A R A M L D I V K R Y N W T Y V S A V H T E G N Y G E S G M D A F K E L A A Q E G L C I A H S D K I Y S N A G E K S F D R L L R K L R E R L P K A R V V V C F C E G M T V R G L L S A M R R L G V V G E F S L I G S D G W A D R D E V I E G Y E V E A N G G I T I K L Q S P E V R S F D D Y F L K L R L D T N T R N P W F P E F W Q H R F Q C R L P G H L L E N P N F K R I C T G N E S L E E N Y V Q D S K M G F V I N A I Y A M A H G L Q N M H H A L C P G H V G L C D A M K P I D G S K L L D F L I K S S F I G V S G E E V W F D E K G D A P G R Y D I M N L Q Y T E A N R Y D Y V H V G T W H E G V L N I D D Y K I Q M N K S G V V R S V C S E P C L K G Q I K V I R K G E V S C C W I C T A C K E N E Y V Q D E F T C K A C D L G W W P N A D L T G C E P I P V R Y L E W S N N-termC-term D V V R M H V G D G K L P C R S N T F L N I F R R K K A G A G N A N S N G K S V S W S E P G G G Q V P K G Q H M W H R L S V H V K T N E T A C N Q T A V I K P L T K S Y Q G S G K S L T F S D T S T K T L Y N V E E E E D A Q P I R F S P P G S P S M V V H R R V P S A A T T P P L P S H L T A E E T P L F L A E P A L P K G L P P P L Q Q Q Q Q P P P Q Q K S L M D Q L Q G V V S N F S T A I P D F H A V L A G P G G P G N G L R S L Y P P P P P P Q H L Q M L P L Q L S T F G E E L V S P P A D D D D D S E R F K L L Q E Y V Y E H E R E G N T E E D E L E E E E E D L Q A A S K L T P D D S P A L T P P S P F R D S V A S G S S V P S S P V S E S V L C T P P N V S Y A S V I L R D Y K Q S S S T L C-term I E S I I A I A F S C L G I L V T L F V T L I F V L Y S R E L C Y I I L A G I F L G Y V C P F T L I A T T T S C Y L Q R L L V G L S S A M C Y S A L V T K T N R I A R I L S A W A Q V I I A S I L I S V Q L T L V V T L I I M E S N L G V V A P L G Y N G L L I M S C T Y Y A F K T E A K Y I A F T M Y T T C I I W L A F V P I Y F G S Y K I I T T C F A V S L S V T V A L G C M F T P K M Y I I I A K P E R A F T N V R S T S
Helix box plot — Download: PNG | SVG L T V L I G L C S F A I A I I S E I 1 Y I I L A G I F L G Y V C P F T L I A 2 T V L A S Y C M A S S L G V L L R Q L Y 3 Q V I I A S I L I S V Q L T L V V T L I 4 A Y Y T C S M I L L G N Y G L P A V V G 5 A F T M Y T T C I I W L A F V P I Y F G 6 G L A V T V S L S V A F C T T I I K Y 7

GPCRdb(A)
GPCRdb(C)
mGlu1 receptor
TM3
3x40 3.44x44 Y672
TM5
5x44 5.44x44 L757
5x47 5.47x47 N760
5x48 5.48x48 G761
5x51 5.51x51 I764
TM6
6x44 6.46x46 T794
6x45 6.47x47 C795
6x48 6.50x50 W798
6x51 6.53x53 F801
TM7
7x41 7.35x36 A818
7x42 7.36x37 V819
7x45 7.39x40 S822