PDB
9XDR
Resolution
2.6 Å
Released
July 8, 2026
Receptor
κ
Class
A
Species
Homo sapiens
Ligands
Function
asimadoline
Agonist
BMS-986187
Ago-PAM
Reference
—
asimadoline BMS-986187

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Ligand Amino Acid Generic Number Segment Interaction Type
BMS-986187 L107 2.52x52 TM2 hydrophobic
asimadoline V108 2.53x53 TM2 Van der Waals
asimadoline Q115 2.60x60 TM2 Van der Waals
BMS-986187 K132 3.26x26 TM3 hydrophobic
BMS-986187 I133 3.27x27 TM3 hydrophobic
asimadoline V134 3.28x28 TM3 hydrophobic
asimadoline I135 3.29x29 TM3 hydrophobic
BMS-986187 S136 3.30x30 TM3 Van der Waals
BMS-986187 I137 3.31x31 TM3 hydrophobic
asimadoline D138 3.32x32 TM3 polar (hydrogen bond)
asimadoline D138 3.32x32 TM3 polar (charge-charge)
asimadoline D138 3.32x32 TM3 hydrophobic
asimadoline Y139 3.33x33 TM3 aromatic (edge-to-face)
asimadoline Y139 3.33x33 TM3 hydrophobic
BMS-986187 Y140 3.34x34 TM3 hydrophobic
BMS-986187 N141 3.35x35 TM3 Van der Waals
asimadoline M142 3.36x36 TM3 Van der Waals
BMS-986187 S187 4.54x54 TM4 Van der Waals
BMS-986187 G190 4.57x57 TM4 Van der Waals
BMS-986187 I191 4.58x58 TM4 hydrophobic
BMS-986187 I194 4.61x61 TM4 hydrophobic
asimadoline L212 45.52x52 ECL2 hydrophobic
asimadoline W287 6.48x48 TM6 hydrophobic
asimadoline I290 6.51x51 TM6 hydrophobic
asimadoline H291 6.52x52 TM6 aromatic (edge-to-face)
asimadoline I316 7.39x38 TM7 Van der Waals
asimadoline G319 7.42x41 TM7 Van der Waals
asimadoline Y320 7.43x42 TM7 hydrophobic
asimadoline Y320 7.43x42 TM7 aromatic (pi-cation)

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Download PDB file

Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 S W P F ECL1ICL2 P V K A L D F R ICL2ECL2 G T K V R E D V D V I E C S L Q F P D D ECL2ICL3 R L L S G ICL3ECL3 S T S H ECL3N-term M D S P I Q I F R G E P G P T C A P S A C L P P N S S A W F P G W A E P D S N G S A G S E D A Q L E P A H I S P N-termC-term P L K M R M E R Q S T S R V R N T V Q D P A Y L R D I D G M N K P V C-term A I P V I I T A V Y S V V F V V G L V G N S L V M F V I I R Y T A T N I Y I F N L A L A D A L V T T T M P F Q S T V Y L M N G D V L C K I V I S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H T P L K A K I I N I C I W L L S S S V G I S A I V L G D Y S W W D L F M K I C V F I F A F V I P V L I I I V C Y T L M I L R L K S V S R E K D R N L R R I T R L V L V V V A V F V V C W T P I H I F I L V E A L G S T A A L S S Y Y F C I A L G Y T N S S L N P I L Y A F L D E N F R D F K R C F C F
Helix box plot — Download: PNG | SVG S N G V L G V V F V V S Y V A T I I V P 1 F N L A L A D A L V T T T M P F Q S T V 2 M T L T F I S T F M N Y Y D I S I V I K 3 A K I I N I C I W L L S S S V G I S A I 4 Y C V I I I L V P I V F A F I F V C I K M 5 L V V V A V F V V C W T P I H I F I L V 6 I P N L S S N T Y G L A I C F Y Y S S 7

GPCRdb(A)
GPCRdb(A)
κ receptor
TM2
2x52 2.52x52 L107
2x53 2.53x53 V108
2x60 2.60x60 Q115
TM3
3x26 3.26x26 K132
3x27 3.27x27 I133
3x28 3.28x28 V134
3x29 3.29x29 I135
3x30 3.30x30 S136
3x31 3.31x31 I137
3x32 3.32x32 D138
3x33 3.33x33 Y139
3x34 3.34x34 Y140
3x35 3.35x35 N141
3x36 3.36x36 M142
TM4
4x54 4.54x54 S187
4x57 4.57x57 G190
4x58 4.58x58 I191
4x61 4.61x61 I194
ECL2
45x52 45.52x52 L212
TM6
6x48 6.48x48 W287
6x51 6.51x51 I290
6x52 6.52x52 H291
TM7
7x38 7.39x38 I316
7x41 7.42x41 G319
7x42 7.43x42 Y320