QAV680


SMILES OC(=O)Cc1c(C)n(c2c1cccn2)Cc1ccc(cc1)S(=O)(=O)C
InChIKey YOPFAMROKXHVCQ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 5
Molecular weight (Da) 358.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
DP2 PD2R2 Human Prostanoid A pKd 7.82 7.82 7.82 Guide to Pharmacology
DP2 PD2R2 Human Prostanoid A pKi 7.44 7.47 7.54 ChEMBL
DP2 PD2R2 Human Prostanoid A pKd 7.82 7.82 7.82 ChEMBL
DP2 PD2R2 Mouse Prostanoid A pKi 8.0 8.0 8.0 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
DP2 PD2R2 Human Prostanoid A pIC50 6.99 7.82 8.52 ChEMBL
DP2 PD2R2 Mouse Prostanoid A pIC50 7.03 7.03 7.03 ChEMBL