Compound 30 [Pmid: 21757343]
Chemical Properties
| SMILES | Clc1cccc(c1)c1ncc(c(c1)C)[C@H]1CCCN1C(=O)c1nccs1 |
| Hydrogen bond acceptors | 4 |
| Hydrogen bond donors | 0 |
| Rotatable bonds | 3 |
| Molecular weight | 383.1 |
Drug Properties
| Type | Small molecule |
| Endogenous | No |
| Approved | No |
| InChIKey | GCSDBTCZHROCLZ-GOSISDBHSA-N |
Bioactivity
| Receptor | Experimental Data | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| mGlu5 | GRM5 | Human | Metabotropic glutamate | C | pKi | 7.92 | 7.92 | 7.92 | Guide to Pharmacology |
| mGlu5 | GRM5 | Human | Metabotropic glutamate | C | pIC50 | 7.77 | 7.77 | 7.77 | Guide to Pharmacology |
| mGlu5 | GRM5 | Rat | Metabotropic glutamate | C | pIC50 | 7.92 | 7.92 | 7.92 | Guide to Pharmacology |
| mGlu5 | GRM5 | Human | Metabotropic glutamate | C | pKi | 7.92 | 7.92 | 7.92 | ChEMBL |
| mGlu5 | GRM5 | Human | Metabotropic glutamate | C | pIC50 | 7.77 | 7.77 | 7.77 | ChEMBL |