CHEMBL3321792


SMILES OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccccc1F
InChIKey QHLAPIQLWATZKM-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 6
Molecular weight (Da) 405.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D4 DRD4 Rat Dopamine A pKi 7.57 7.57 7.57 ChEMBL
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 5.95 5.95 5.95 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 6.05 6.05 6.05 ChEMBL
H1 HRH1 Human Histamine A pKi 6.0 6.0 6.0 ChEMBL
D1 DRD1 Human Dopamine A pKi 5.39 5.39 5.39 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.28 6.28 6.28 ChEMBL
D3 DRD3 Human Dopamine A pKi 8.89 8.89 8.89 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.94 6.94 6.94 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.09 8.09 8.09 ChEMBL
D2 DRD2 Human Dopamine A pKi 8.32 8.32 8.32 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database