GproteinDb

CP 376,395

Agent/drug
Bioactivity

CP 376,395

SMILES	CCC(CC)Nc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C
InChIKey	VIZBSVDBNLAVAW-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	1
Rotatable bonds	6
Molecular weight (Da)	326.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Structure pdb	4K5Y 4Z9G
Ligand site mutations	CRF₁

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

CRF₁	CRFR1	Rat	Corticotropin-releasing factor	B1	pKi	7.92	7.92	7.92	ChEMBL
CRF₁	CRFR1	Human	Corticotropin-releasing factor	B1	pKi	7.92	7.92	7.92	ChEMBL

Showing 1 to 2 of 2 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

CRF₁	CRFR1	Rat	Corticotropin-releasing factor	B1	pIC50	8.30	8.30	8.30	Guide to Pharmacology
CRF₁	CRFR1	Rat	Corticotropin-releasing factor	B1	pIC50	8.29	8.29	8.29	ChEMBL

Showing 1 to 2 of 2 entries

CP 376,395

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Structure pdb	4K5Y 4Z9G
Ligand site mutations	CRF₁

Compound is not listed as a drug.