CHEMBL3287396


SMILES OCc1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1
InChIKey PIZUPLOSIUAOMH-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 8
Molecular weight (Da) 448.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D1 DRD1 Human Dopamine A pKi 6.62 6.62 6.62 ChEMBL
D2 DRD2 Human Dopamine A pKi 8.51 8.57 8.64 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.8 7.8 7.8 ChEMBL
D3 DRD3 Human Dopamine A pKi 8.89 8.89 8.89 ChEMBL
D4 DRD4 Human Dopamine A pKi 7.46 7.46 7.46 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D2 DRD2 Human Dopamine A pEC50 6.27 6.27 6.27 ChEMBL
D3 DRD3 Human Dopamine A pEC50 8.23 8.23 8.23 ChEMBL