CHEMBL3616849


SMILES N[C@@]1(C(=O)O)C[C@@H](Sc2nnc(C(F)(F)F)[nH]2)[C@H]2[C@H](C(=O)O)[C@H]21
InChIKey HHUBIRLCPJRLDB-UESLGPDASA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 4
Rotatable bonds 4
Molecular weight (Da) 352.0

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu2 GRM2 Human Metabotropic glutamate C pKi 7.07 7.07 7.07 ChEMBL
mGlu3 GRM3 Human Metabotropic glutamate C pKi 7.25 7.25 7.25 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu2 GRM2 Human Metabotropic glutamate C pEC50 7.27 7.56 7.86 ChEMBL
mGlu3 GRM3 Human Metabotropic glutamate C pEC50 7.09 7.09 7.1 ChEMBL
mGlu3 GRM3 Human Metabotropic glutamate C pIC50 6.28 6.28 6.28 ChEMBL