Dapiprazole

Chemical Properties

SMILES Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2
Hydrogen bond acceptors 5
Hydrogen bond donors 0
Rotatable bonds 4
Molecular weight 325.2

Drug Properties

Type Small molecule
Endogenous No
Approved Yes
InChIKey RFWZESUMWJKKRN-UHFFFAOYSA-N

Bioactivity

Receptor Experimental Data Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α1D ADA1D Human Adrenoceptors A pKi 8.4 8.4 8.4 Guide to Pharmacology
α1B ADA1B Rat Adrenoceptors A pIC50 7.26 7.26 7.26 ChEMBL
α1B ADA1B Rat Adrenoceptors A pKi 7.52 7.52 7.52 ChEMBL
α2B ADA2B Human Adrenoceptors A pIC50 5.94 5.94 5.94 ChEMBL
α2B ADA2B Human Adrenoceptors A pKi 6.28 6.28 6.28 ChEMBL
α1A ADA1A Rat Adrenoceptors A pIC50 7.02 7.02 7.02 ChEMBL
α1A ADA1A Rat Adrenoceptors A pKi 7.41 7.41 7.41 ChEMBL
α1D ADA1D Human Adrenoceptors A pIC50 8.08 8.08 8.08 ChEMBL
α1D ADA1D Human Adrenoceptors A pKi 8.39 8.39 8.39 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pIC50 5.98 5.98 5.98 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.17 6.17 6.17 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pIC50 5.69 5.69 5.69 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 5.93 5.93 5.93 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pIC50 6.2 6.2 6.2 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.49 6.49 6.49 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pIC50 6.22 6.22 6.22 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.76 6.76 6.76 ChEMBL