GproteinDb

CHEMBL365751

Agent/drug
Bioactivity

CHEMBL365751

SMILES	Cc1[nH]c2ccc(Cl)cc2c1CCN(C)C
InChIKey	KSYMELKKLOFABL-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	1
Hydrogen bond donors	1
Rotatable bonds	3
Molecular weight (Da)	236.1

Database connections

ChEMBL_compound_ids PubChem GPCRdb
Structure pdb	8JLZ
Ligand site mutations	5-HT₆

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	6.61	6.61	6.61	ChEMBL
5-HT₆	5HT6R	Rat	5-Hydroxytryptamine	A	pKi	7.54	7.54	7.54	ChEMBL
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	6.54	6.54	6.54	ChEMBL

Showing 1 to 3 of 3 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pIC50	7.40	7.40	7.40	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pEC50	7.35	7.35	7.35	ChEMBL

Showing 1 to 2 of 2 entries

CHEMBL365751

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

ChEMBL_compound_ids PubChem GPCRdb
Structure pdb	8JLZ
Ligand site mutations	5-HT₆

Compound is not listed as a drug.