CHEMBL1086105


SMILES Cc1cc(OCCCN2CCc3nc[nH]c3C2)ccc1-c1nc2c(C)c(F)ccc2[nH]1
InChIKey MGPIMNVSULKFFK-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 6
Molecular weight (Da) 419.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H4 HRH4 Mouse Histamine A pKd 4.8 4.8 4.8 ChEMBL
H4 HRH4 Human Histamine A pKi 8.48 8.48 8.48 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H4 HRH4 Mouse Histamine A pEC50 7.92 7.92 7.92 ChEMBL
H4 HRH4 Human Histamine A pEC50 8.48 8.48 8.48 ChEMBL
H2 HRH2 Human Histamine A pEC50 6.88 6.88 6.88 ChEMBL
H3 HRH3 Human Histamine A pEC50 6.42 6.42 6.42 ChEMBL