GproteinDb

doxazosin

Agent/drug
Bioactivity

doxazosin

SMILES	COc1cc2nc(N3CCN(C(=O)C4COc5ccccc5O4)CC3)[nH]c(=N)c2cc1OC
InChIKey	RUZYUOTYCVRMRZ-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	8
Hydrogen bond donors	2
Rotatable bonds	4
Molecular weight (Da)	451.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.40	8.85	9.30	Guide to Pharmacology
α_1A	ADA1A	Rat	Adrenoceptors	A	pKd	8.69	8.69	8.69	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	9.20	9.20	9.20	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.50	8.95	9.27	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKd	7.59	7.59	7.59	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.06	8.06	8.06	Drug Central
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.50	8.80	9.10	Guide to Pharmacology
α_1B	ADA1B	Rat	Adrenoceptors	A	pKd	9.51	9.51	9.51	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	9.38	9.38	9.38	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	9.00	9.10	9.20	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	9.00	9.00	9.00	PDSP Ki database
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.04	8.04	8.04	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.03	8.03	8.03	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.30	8.70	9.10	Guide to Pharmacology
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.40	8.96	9.49	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.50	8.50	8.50	PDSP Ki database
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.05	8.05	8.05	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.14	6.14	6.14	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.21	8.21	8.21	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.55	6.55	6.55	ChEMBL

Showing 1 to 20 of 28 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	8.81	8.97	9.13	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	8.06	8.06	8.06	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pIC50	9.12	9.12	9.12	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	8.47	8.47	8.47	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pIC50	5.56	5.56	5.56	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	6.43	6.43	6.43	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	6.26	6.26	6.26	ChEMBL

Showing 1 to 7 of 7 entries

doxazosin

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 3

Phase II 12

Phase III 12

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Acute myocardial infarction, unspecified	BA41.Z	C02C	0.489	4	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Alcohol dependence, unspecified	6C40.2Z	C02C	0.453	2	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Calculus of kidney, unspecified	GB70.0Z	C02C	0.577	3	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Cocaine dependence, unspecified	6C45.2Z	C02C	0.108	2	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Diseases of the circulatory system, unspecified	BE2Z	C02C	0.596	3	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Essential hypertension, unspecified	BA00.Z	C02C	0.444	4	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Heart failure, unspecified	BD1Z	C02C	0.593	3	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Hyperplasia of prostate	GA90	C02C	0.450	4	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Ischaemic heart diseases, unspecified	BA6Z	C02C	0.259	3	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Nicotine dependence, unspecified	6C4A.2Z	C02C	0.102	2	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Post traumatic stress disorder	6B40	C02C	0.548	2	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Unknown or unspecified psychoactive substance dependence, substance and state of remission unspecified	6C4G.2Z	C02C	0.037	1	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Acute myocardial infarction, unspecified	BA41.Z	C02C	0.487	4	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Alcohol dependence, unspecified	6C40.2Z	C02C	0.453	2	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Calculus of kidney, unspecified	GB70.0Z	C02C	0.570	3	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Cocaine dependence, unspecified	6C45.2Z	C02C	0.108	2	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Diseases of the circulatory system, unspecified	BE2Z	C02C	0.591	3	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Essential hypertension, unspecified	BA00.Z	C02C	0.439	4	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Heart failure, unspecified	BD1Z	C02C	0.593	3	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Hyperplasia of prostate	GA90	C02C	0.447	4	Yes

Showing 1 to 20 of 36 entries

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doxazosin

doxazosin

Chemical Properties

Database connections

Bioactivities

doxazosin

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information