Fenobam

Chemical Properties

SMILES O=C(NC1=NC(=O)CN1C)Nc1cccc(c1)Cl
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 1
Molecular weight 266.1

Drug Properties

Type Small molecule
Endogenous No
Approved Yes
InChIKey DWPQODZAOSWNHB-UHFFFAOYSA-N

Database Connections

External Links
Structure pdb 6FFH
Ligand site mutations mGlu5


Bioactivity

Receptor Experimental Data Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Human Metabotropic glutamate C pIC50 7.2 7.2 7.2 Guide to Pharmacology
mGlu5 GRM5 Human Metabotropic glutamate C pKd 7.5 7.5 7.5 Guide to Pharmacology
mGlu5 GRM5 Rat Metabotropic glutamate C pKd 7.3 7.3 7.3 Guide to Pharmacology
mGlu1 GRM1 Human Metabotropic glutamate C pKi 8.17 8.17 8.17 ChEMBL
mGlu5 GRM5 Rat Metabotropic glutamate C pIC50 6.34 6.81 7.29 ChEMBL
mGlu5 GRM5 Rat Metabotropic glutamate C pKi 6.5 6.5 6.5 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pIC50 6.48 7.24 7.44 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pKi 6.79 7.35 8.17 ChEMBL