GproteinDb

fexofenadine

Agent/drug
Bioactivity

fexofenadine

SMILES	CC(C)(C(=O)O)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1
InChIKey	RWTNPBWLLIMQHL-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	3
Rotatable bonds	10
Molecular weight (Da)	501.3

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem PubChem GPCRdb
Ligand site mutations	H₁

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

D₂	DRD2	Human	Dopamine	A	pKi	5.05	5.05	5.05	ChEMBL
D₃	DRD3	Human	Dopamine	A	pKi	5.63	5.63	5.63	ChEMBL
H₁	HRH1	Human	Histamine	A	pKi	7.57	7.57	7.57	Guide to Pharmacology
H₁	HRH1	Human	Histamine	A	pKi	7.03	7.30	7.57	ChEMBL
H₁	HRH1	Human	Histamine	A	pKi	5.00	7.14	8.00	PDSP Ki database
H₁	HRH1	Human	Histamine	A	pKi	8.10	8.10	8.10	Drug Central

Showing 1 to 6 of 6 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

H₁	HRH1	Human	Histamine	A	pIC50	7.11	7.29	7.82	ChEMBL

Showing 1 to 1 of 1 entry

fexofenadine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 1

Phase II 3

Phase III 2

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem PubChem GPCRdb
Ligand site mutations	H₁

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Allergic or hypersensitivity conditions of unspecified type	4A8Z	R06A	0.494	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Allergic rhinitis due to other seasonal allergens	CA08.01	R06A	0.610	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Allergic rhinitis, unspecified	CA08.0Z	R06A	0.616	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Asthma	CA23	R06A	0.545	3	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Atopic eczema, unspecified	EA80.Z	R06A	0.474	2	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Calculus of kidney, unspecified	GB70.0Z	R06A	0.092	2	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Chronic kidney disease, stage unspecified	GB61.Z	R06A	0.140	3	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Gastro-oesophageal reflux disease, unspecified	DA22.Z	R06A	0.038	2	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Rheumatoid arthritis, serology unspecified	FA20.Z	R06A	0.441	1	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Urticaria of unspecified type	EB05	R06A	0.606	4	Yes

Showing 1 to 10 of 10 entries