GproteinDb

fluoxetine

Agent/drug
Bioactivity

fluoxetine

SMILES	CNCCC(Oc1ccc(C(F)(F)F)cc1)c1ccccc1
InChIKey	RTHCYVBBDHJXIQ-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	1
Rotatable bonds	6
Molecular weight (Da)	309.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central GPCRdb
Ligand site mutations	5-HT_2A 5-HT_2C

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.24	8.24	8.24	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	5.70	5.70	5.70	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.20	8.20	8.20	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.09	8.09	8.09	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.16	6.16	6.16	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.21	8.21	8.21	Drug Central
β₁	ADRB1	Human	Adrenoceptors	A	pKi	8.27	8.27	8.27	Drug Central
β₂	ADRB2	Rat	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.03	5.08	PDSP Ki database
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	5.21	5.21	5.21	PDSP Ki database
5-HT_1D	F1MMU1	Bovine	5-Hydroxytryptamine	A	pKi	5.37	5.37	5.37	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	7.26	7.26	7.26	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	6.61	6.76	6.85	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.18	8.18	8.18	Drug Central
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	5.30	5.30	5.30	Guide to Pharmacology
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	5.00	5.10	5.30	PDSP Ki database
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.28	8.28	8.28	Drug Central
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	7.30	7.30	7.30	Guide to Pharmacology
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	7.14	7.17	7.21	ChEMBL

Showing 1 to 20 of 56 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	5.82	5.82	5.82	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	6.15	6.43	6.71	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	6.80	6.86	6.92	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pIC50	5.78	5.78	5.78	ChEMBL
apelin	APJ	Human	Apelin	A	pIC50	5.47	5.47	5.47	ChEMBL
CX₃CR1	CX3C1	Human	Chemokine	A	pIC50	5.52	5.52	5.52	ChEMBL
GPR183	GP183	Human	A orphans	A	pIC50	5.18	5.18	5.18	ChEMBL
GPR35	GPR35	Human	A orphans	A	pIC50	5.08	5.08	5.08	ChEMBL
GPR65	PSYR	Human	A orphans	A	pIC50	5.58	5.58	5.58	ChEMBL
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pIC50	5.49	5.49	5.49	ChEMBL
M₃	ACM3	Human	Acetylcholine (muscarinic)	A	pIC50	5.44	5.44	5.44	ChEMBL
M₅	ACM5	Human	Acetylcholine (muscarinic)	A	pIC50	5.87	5.87	5.87	ChEMBL

Showing 1 to 12 of 12 entries

fluoxetine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved No

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central GPCRdb
Ligand site mutations	5-HT_2A 5-HT_2C

Compound is not listed as a drug.