CHEMBL4282702


SMILES OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCCc2ccc(F)cc2)CC1
InChIKey UBNDBTRGSCEYOS-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight (Da) 443.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D4 DRD4 Human Dopamine A pKi 6.88 6.88 6.88 ChEMBL
μ OPRM Human Opioid A pKi 6.27 6.27 6.27 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.04 6.04 6.04 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 5.35 5.35 5.35 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.05 6.05 6.05 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.59 5.59 5.59 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 5.95 5.95 5.95 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.34 6.34 6.34 ChEMBL
H1 HRH1 Human Histamine A pKi 6.14 6.14 6.14 ChEMBL
H2 HRH2 Human Histamine A pKi 6.4 6.4 6.4 ChEMBL
κ OPRK Human Opioid A pKi 5.77 5.77 5.77 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database