CHEMBL4300899


SMILES COc1ccccc1N1CCN(CCCOc2ccc(C)cc2C)CC1
InChIKey RRGONONIXNMNQE-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 7
Molecular weight (Da) 354.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 7.82 7.82 7.82 ChEMBL
α1A ADA1A Human Adrenoceptors A pKi 7.96 7.96 7.96 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.28 6.28 6.28 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.7 8.7 8.7 ChEMBL
D2 DRD2 Human Dopamine A pKi 7.01 7.01 7.01 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pIC50 5.98 5.98 5.98 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pIC50 8.14 8.14 8.14 ChEMBL
D2 DRD2 Human Dopamine A pIC50 7.75 7.75 7.75 ChEMBL