CHEMBL4442548


SMILES CCc1cccc(NC(=O)CN2CCN(c3ccccn3)CC2)c1
InChIKey FJYJGNZBZKNLBF-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 5
Molecular weight (Da) 324.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D4 DRD4 Human Dopamine A pKi 7.17 7.91 8.65 ChEMBL
D3 DRD3 Human Dopamine A pKi 5.83 5.83 5.83 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.22 6.22 6.22 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D4 DRD4 Human Dopamine A pEC50 6.88 7.21 7.54 ChEMBL
D4 DRD4 Human Dopamine A pIC50 5.88 6.15 6.43 ChEMBL
D3 DRD3 Human Dopamine A pEC50 5.56 5.56 5.56 ChEMBL
D3 DRD3 Human Dopamine A pIC50 4.05 4.05 4.05 ChEMBL
D2 DRD2 Human Dopamine A pEC50 5.41 5.61 5.8 ChEMBL
D2 DRD2 Human Dopamine A pIC50 4.05 4.22 4.39 ChEMBL