NANTENINE


SMILES COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4
InChIKey WSVWKHTVFGTTKJ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 0
Rotatable bonds 2
Molecular weight (Da) 339.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 5.65 5.65 5.65 ChEMBL
D5 DRD5 Human Dopamine A pKi 5.62 5.62 5.62 ChEMBL
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 7.0 7.0 7.0 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 7.31 7.31 7.31 ChEMBL
α1B ADA1B Human Adrenoceptors A pKi 5.92 5.92 5.92 ChEMBL
α2B ADA2B Human Adrenoceptors A pKi 6.6 6.6 6.6 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 6.74 6.74 6.74 ChEMBL
α1A ADA1A Human Adrenoceptors A pKi 8.7 8.7 8.7 ChEMBL
H2 HRH2 Human Histamine A pKi 6.17 6.17 6.17 ChEMBL
α1D ADA1D Human Adrenoceptors A pKi 6.47 6.47 6.47 ChEMBL
β1 ADRB1 Human Adrenoceptors A pKi 5.07 5.07 5.07 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 5.89 5.89 5.89 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.26 6.26 6.26 ChEMBL
D1 DRD1 Human Dopamine A pKi 6.05 6.05 6.05 ChEMBL
D4 DRD4 Human Dopamine A pKi 6.58 6.58 6.58 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 6.59 6.59 6.59 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.08 6.08 6.08 ChEMBL
D3 DRD3 Human Dopamine A pKi 6.51 6.51 6.51 ChEMBL
μ OPRM Human Opioid A pKi 5.14 5.14 5.14 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.07 6.07 6.07 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.97 5.97 5.97 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 7.17 7.17 7.17 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database