CHEMBL446543


SMILES Cc1nc(C#Cc2cc(F)cc(C#N)c2)cs1
InChIKey YPCGRVYMABSMOQ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 0
Molecular weight (Da) 242.0

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Rat Metabotropic glutamate C pKi 9.44 9.77 10.1 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pKi 9.05 9.05 9.05 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Rat Metabotropic glutamate C pIC50 8.72 8.91 9.09 ChEMBL