8-OH-DPAT


SMILES CCCN(C1CCc2c(C1)c(O)ccc2)CCC
InChIKey ASXGJMSKWNBENU-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 5
Molecular weight (Da) 247.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Ligand site mutations 5-HT1A 5-HT1B 5-HT2C

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKd 8.9 8.9 8.9 Guide to Pharmacology
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 6.9 7.1 7.3 Guide to Pharmacology
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKd 9.0 9.0 9.0 Guide to Pharmacology
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 5.5 5.5 5.5 Guide to Pharmacology
5-HT1F 5HT1F Human 5-Hydroxytryptamine A pKi 5.8 5.8 5.8 Guide to Pharmacology
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 5.6 5.6 5.6 Guide to Pharmacology
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.6 5.6 5.6 Guide to Pharmacology
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 5.6 5.65 5.7 Guide to Pharmacology
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 6.3 6.95 7.6 Guide to Pharmacology
5-HT7 5HT7R Mouse 5-Hydroxytryptamine A pKi 6.6 6.6 6.6 Guide to Pharmacology
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 7.3 7.4 7.5 Guide to Pharmacology
5-HT2B 5HT2B Rat 5-Hydroxytryptamine A pKi 5.4 5.4 5.4 Guide to Pharmacology
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 6.82 6.82 6.82 ChEMBL
D3 DRD3 Rat Dopamine A pKi 6.48 6.56 6.61 ChEMBL
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 5.6 5.73 6.0 ChEMBL
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 4.2 4.89 5.59 ChEMBL
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 6.2 6.22 6.25 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 6.79 6.87 6.94 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 6.3 6.37 6.41 ChEMBL
D2 DRD2 Rat Dopamine A pKi 5.46 6.18 7.07 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 6.01 8.78 9.57 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKd 8.6 8.6 8.6 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 4.83 4.98 5.14 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.4 8.7 9.77 ChEMBL
D2 DRD2 Human Dopamine A pKi 5.49 6.68 7.08 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 5.9 6.48 7.33 PDSP Ki database
5-HT1D 5HT1D Rat 5-Hydroxytryptamine A pKi 6.02 6.29 7.0 PDSP Ki database
5-HT1D F1MMU1 Bovine 5-Hydroxytryptamine A pKi 5.05 5.94 6.7 PDSP Ki database
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 5.0 5.26 6.15 PDSP Ki database
5-HT2B F6QI78 Bovine 5-Hydroxytryptamine A pKi 5.27 5.27 5.27 PDSP Ki database
5-HT2C K7GSR7 Pig 5-Hydroxytryptamine A pKi 5.06 5.41 8.4 PDSP Ki database
D1 DRD1 Human Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 5.0 5.62 5.97 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.48 8.66 10.22 PDSP Ki database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 5.55 6.44 7.42 PDSP Ki database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 5.7 7.17 7.46 PDSP Ki database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 5.0 5.05 5.22 PDSP Ki database
5-HT5A 5HT5A Rat 5-Hydroxytryptamine A pKi 6.0 6.0 6.0 PDSP Ki database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 5.39 5.7 6.05 PDSP Ki database
5-HT2B 5HT2B Rat 5-Hydroxytryptamine A pKi 5.39 5.39 5.39 PDSP Ki database
α2B ADA2B Rat Adrenoceptors A pKi 6.83 6.83 6.83 PDSP Ki database
5-HT7 5HT7R Guinea pig 5-Hydroxytryptamine A pKi 6.87 7.19 7.39 PDSP Ki database
5-HT5A 5HT5A Mouse 5-Hydroxytryptamine A pKi 5.8 5.87 5.9 PDSP Ki database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 6.33 6.55 7.28 PDSP Ki database
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 5.48 5.78 6.08 PDSP Ki database
D3 DRD3 Human Dopamine A pKi 5.66 6.27 6.7 PDSP Ki database
5-HT7 5HT7R Mouse 5-Hydroxytryptamine A pKi 6.6 6.6 6.6 PDSP Ki database
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 7.57 8.83 9.32 PDSP Ki database
5-HT4 5HT4R Rat 5-Hydroxytryptamine A pKi 5.0 5.5 6.0 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 5.0 5.19 5.57 PDSP Ki database
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.0 5.3 5.6 PDSP Ki database
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 5.6 5.6 5.6 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.4 8.9 9.4 Guide to Pharmacology
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKd 6.0 7.7 9.4 Guide to Pharmacology
5-HT1F 5HT1F Human 5-Hydroxytryptamine A pKi 5.75 5.75 5.75 PDSP Ki database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 5.4 5.4 5.4 Guide to Pharmacology
α1A ADA1A Human Adrenoceptors A pKi 5.75 6.29 6.82 ChEMBL
α1B ADA1B Human Adrenoceptors A pKi 5.22 5.39 5.72 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 6.73 6.73 6.73 PDSP Ki database
α2C ADA2C Human Adrenoceptors A pKi 6.93 6.93 6.93 PDSP Ki database
D3 DRD3 Human Dopamine A pKi 4.84 5.71 6.59 ChEMBL
5-HT6 5HT6R Mouse 5-Hydroxytryptamine A pKi 6.6 6.6 6.6 PDSP Ki database
D1 DRD1 Bovine Dopamine A pKi 4.06 4.06 4.06 ChEMBL
α1A ADA1A Rat Adrenoceptors A pKi 5.68 5.68 5.68 ChEMBL
5-HT1A 5HT1A Mouse 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
D2 DRD2 Bovine Dopamine A pKi 5.62 5.62 5.62 ChEMBL
5-HT5A 5HT5A Mouse 5-Hydroxytryptamine A pKi 5.9 5.9 5.9 Guide to Pharmacology
5-HT1A F6Q2H9 Bovine 5-Hydroxytryptamine A pKi 8.9 8.9 8.9 PDSP Ki database
5-HT1A A0A4X1UTF5 Pig 5-Hydroxytryptamine A pKi 8.74 8.77 8.84 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pIC50 6.2 6.2 6.2 Guide to Pharmacology
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pIC50 5.42 5.42 5.42 ChEMBL
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pEC50 6.58 6.58 6.58 ChEMBL
D2 DRD2 Rat Dopamine A pIC50 5.24 6.76 8.28 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pIC50 7.85 8.52 8.96 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pEC50 7.29 7.88 8.59 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pIC50 8.22 9.16 9.55 ChEMBL
5-HT2A 5HT2A Bovine 5-Hydroxytryptamine A pIC50 4.31 4.31 4.31 ChEMBL
D2 DRD2 Bovine Dopamine A pIC50 6.1 6.1 6.1 ChEMBL
α2A ADA2A Bovine Adrenoceptors A pIC50 6.0 6.0 6.0 ChEMBL
α1A ADA1A Bovine Adrenoceptors A pIC50 4.52 4.52 4.52 ChEMBL