GproteinDb

guanfacine

Agent/drug
Bioactivity

guanfacine

SMILES	NC(N)=NC(=O)Cc1c(Cl)cccc1Cl
InChIKey	INJOMKTZOLKMBF-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	1
Hydrogen bond donors	2
Rotatable bonds	2
Molecular weight (Da)	245.0

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	6.26	6.26	6.26	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.20	8.20	8.20	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.60	6.95	7.30	Guide to Pharmacology
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	7.30	7.30	7.30	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	7.03	7.17	7.30	PDSP Ki database
α_2A	ADA2A	Mouse	Adrenoceptors	A	pKi	7.69	7.69	7.69	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	5.80	6.15	6.50	Guide to Pharmacology
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.94	6.94	6.94	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	5.86	5.93	5.99	PDSP Ki database
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	5.40	5.80	6.20	Guide to Pharmacology
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.03	6.03	6.03	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	5.41	5.68	5.95	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	6.07	6.07	6.07	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.22	8.22	8.22	Drug Central
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	5.88	5.88	5.88	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.23	8.23	8.23	Drug Central
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	6.12	6.12	6.12	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.21	8.21	8.21	Drug Central

Showing 1 to 18 of 18 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	5.87	5.87	5.87	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	8.23	8.23	8.23	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pEC50	7.60	7.60	7.60	Guide to Pharmacology
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	8.00	8.00	8.00	Guide to Pharmacology
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	6.87	6.87	6.87	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pEC50	7.93	7.93	7.93	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pEC50	8.14	8.14	8.14	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pEC50	8.05	8.05	8.05	Guide to Pharmacology
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	8.70	8.70	8.70	Guide to Pharmacology
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	6.60	6.60	6.60	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pEC50	8.23	8.23	8.23	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pEC50	8.00	8.00	8.00	Guide to Pharmacology
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	7.20	7.20	7.20	Guide to Pharmacology
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	5.19	5.19	5.19	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pEC50	8.25	8.25	8.25	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	5.52	5.52	5.52	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	5.68	5.68	5.68	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	5.84	5.84	5.84	ChEMBL
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	7.90	7.90	7.90	ChEMBL

Showing 1 to 19 of 19 entries

guanfacine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 3

Phase II 24

Phase III 9

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Alcohol dependence, unspecified	6C40.2Z	C02A	0.173	2	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Alzheimer disease	8A20	C02A	0.271	3	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Attention deficit hyperactivity disorder, presentation unspecified	6A05.Z	C02A	0.609	4	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Cannabis dependence, unspecified	6C41.2Z	C02A	0.107	2	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Cocaine dependence, unspecified	6C45.2Z	C02A	0.107	2	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Delirium, unspecified or unknown cause	6D70.Z	C02A	0.599	3	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Essential hypertension, unspecified	BA00.Z	C02A	0.600	4	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Nicotine dependence, unspecified	6C4A.2Z	C02A	0.098	2	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Pain, unspecified	MG3Z	C02A	0.605	2	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Post traumatic stress disorder	6B40	C02A	0.523	1	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Schizotypal disorder	6A22	C02A	0.388	2	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Tourette syndrome	8A05.00	C02A	0.493	3	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Unknown or unspecified psychoactive substance dependence, substance and state of remission unspecified	6C4G.2Z	C02A	0.479	2	Yes
ADA2B	α_2B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Alcohol dependence, unspecified	6C40.2Z	C02A	0.172	2	Yes
ADA2B	α_2B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Alzheimer disease	8A20	C02A	0.389	3	Yes
ADA2B	α_2B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Attention deficit hyperactivity disorder, presentation unspecified	6A05.Z	C02A	0.602	4	Yes
ADA2B	α_2B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Cannabis dependence, unspecified	6C41.2Z	C02A	0.107	2	Yes
ADA2B	α_2B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Cocaine dependence, unspecified	6C45.2Z	C02A	0.106	2	Yes
ADA2B	α_2B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Delirium, unspecified or unknown cause	6D70.Z	C02A	0.599	3	Yes
ADA2B	α_2B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Essential hypertension, unspecified	BA00.Z	C02A	0.600	4	Yes

Showing 1 to 20 of 39 entries

Join us

Cite us

Main reference

guanfacine

guanfacine

Chemical Properties

Database connections

Bioactivities

guanfacine

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information