CHEMBL515472


SMILES COc1c(OCCF)cccc1[C@H](O)C1CCN(CCc2ccc(F)cc2)CC1
InChIKey QCFZUTYIUYQTPW-JOCHJYFZSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 9
Molecular weight (Da) 405.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 5.17 5.17 5.17 ChEMBL
D5 DRD5 Human Dopamine A pKi 5.13 5.13 5.13 ChEMBL
α1B ADA1B Human Adrenoceptors A pKi 6.3 6.3 6.3 ChEMBL
H2 HRH2 Human Histamine A pKi 5.62 5.62 5.62 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 7.23 7.23 7.23 ChEMBL
H1 HRH1 Human Histamine A pKi 6.29 6.29 6.29 ChEMBL
D4 DRD4 Human Dopamine A pKi 6.36 6.36 6.36 ChEMBL
α1A ADA1A Human Adrenoceptors A pKi 6.47 6.47 6.47 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.15 7.21 7.28 ChEMBL
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 6.05 6.05 6.05 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 5.97 5.97 5.97 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.5 6.5 6.5 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 5.42 5.42 5.42 ChEMBL
D1 DRD1 Human Dopamine A pKi 5.42 5.42 5.42 ChEMBL
D2 DRD2 Human Dopamine A pKi 5.57 5.57 5.57 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database