THIOPROPERAZINE


SMILES CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1
InChIKey VZYCZNZBPPHOFY-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 6
Molecular weight (Da) 446.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D2 DRD2 Human Dopamine A pKi 9.35 9.35 9.35 PDSP Ki database
D3 DRD3 Human Dopamine A pKi 8.92 8.92 8.92 PDSP Ki database
D3 DRD3 Rat Dopamine A pKi 8.77 8.77 8.77 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 9.68 9.68 9.68 PDSP Ki database
D4 DRD4 Rat Dopamine A pKi 7.28 7.28 7.28 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 8.03 8.03 8.03 Drug Central
D3 DRD3 Human Dopamine A pKi 8.05 8.05 8.05 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database