REL-CISAPRIDE


SMILES COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCOc2ccc(F)cc2)C[C@H]1OC
InChIKey DCSUBABJRXZOMT-RBBKRZOGSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 9
Molecular weight (Da) 465.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT4 5HT4R Human 5-Hydroxytryptamine A pKi 7.0 7.0 7.0 ChEMBL
5-HT4 5HT4R Guinea pig 5-Hydroxytryptamine A pKi 7.7 7.7 7.7 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT4 5HT4R Rat 5-Hydroxytryptamine A pEC50 6.99 6.99 6.99 ChEMBL
5-HT4 5HT4R Human 5-Hydroxytryptamine A pEC50 7.1 7.4 7.7 ChEMBL
5-HT4 5HT4R Human 5-Hydroxytryptamine A pIC50 6.32 6.32 6.32 ChEMBL