CHEMBL71327


SMILES O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccccc1
InChIKey DHOCETPWLQILEE-SNAWJCMRSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 6
Molecular weight (Da) 403.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D3 DRD3 Rat Dopamine A pKi 8.89 8.89 8.89 ChEMBL
D2 DRD2 Rat Dopamine A pKi 7.3 7.3 7.3 ChEMBL
D3 DRD3 Human Dopamine A pKi 8.22 8.81 9.1 ChEMBL
D2 DRD2 Human Dopamine A pKi 7.63 8.24 8.54 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D3 DRD3 Human Dopamine A pIC50 8.11 8.11 8.11 ChEMBL
D2 DRD2 Human Dopamine A pIC50 7.79 7.79 7.79 ChEMBL