GproteinDb

irbesartan

Agent/drug
Bioactivity

irbesartan

SMILES	CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
InChIKey	YOSHYTLCDANDAN-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	5
Hydrogen bond donors	1
Rotatable bonds	7
Molecular weight (Da)	428.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central Guide To Pharmacology PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

AT₁	AGTR1	Human	Angiotensin	A	pKd	8.71	8.71	8.71	Guide to Pharmacology
AT₁	AGTRB	Rat	Angiotensin	A	pKi	9.10	9.10	9.10	ChEMBL
AT₁	AGTR1	Human	Angiotensin	A	pKi	8.70	8.91	9.10	ChEMBL
AT₁	AGTR1	Human	Angiotensin	A	pKi	8.04	8.04	8.04	Drug Central
AT₁	AGTRB	Rat	Angiotensin	A	pKi	8.04	8.04	8.04	Drug Central
ET_A	EDNRA	Human	Endothelin	A	pKi	5.00	5.00	5.00	ChEMBL
ET_A	EDNRA	Human	Endothelin	A	pKi	8.30	8.30	8.30	Drug Central

Showing 1 to 7 of 7 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

AT₁	AGTR1	Human	Angiotensin	A	pIC50	8.70	8.75	8.80	Guide to Pharmacology
AT₁	AGTRA	Rat	Angiotensin	A	pIC50	9.05	9.05	9.05	ChEMBL
AT₁	AGTRB	Rat	Angiotensin	A	pIC50	8.89	8.89	8.89	ChEMBL
AT₁	AGTR1	Human	Angiotensin	A	pIC50	7.68	8.14	8.52	ChEMBL
BLT₂	LT4R2	Human	Leukotriene	A	pEC50	6.39	6.39	6.39	ChEMBL

Showing 1 to 5 of 5 entries

irbesartan

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 2

Phase III 9

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central Guide To Pharmacology PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Acute kidney failure, stage unspecified	GB60.Z	C09D, C09C	0.262	3	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Acute non-ST elevation myocardial infarction	BA41.1	C09D, C09C	0.259	3	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Atrial fibrillation, unspecified	BC81.3Z	C09D, C09C	0.587	3	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Chronic kidney disease, stage unspecified	GB61.Z	C09D, C09C	0.595	4	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Congestive heart failure	BD10	C09D, C09C	0.599	3	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Ebola disease, virus unspecified	1D60.0Z	C09D, C09C	0.037	2	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Essential hypertension, unspecified	BA00.Z	C09D, C09C	0.708	4	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Hepatic fibrosis	DB93.0	C09D, C09C	0.039	3	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Marfan syndrome	LD28.01	C09D, C09C	0.398	2	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Nephritic syndrome	GB40	C09D, C09C	0.366	3	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Other specified clinical findings in specimens from the urinary system	MF8Y	C09D, C09C	0.356	3	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Other specified types of Ehlers-Danlos syndrome	LD28.1Y	C09D, C09C	0.259	3	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Sepsis without septic shock	1G40	C09D, C09C	0.265	3	Yes

Showing 1 to 13 of 13 entries