GproteinDb

DESIPRAMINE

Agent/drug
Bioactivity

DESIPRAMINE

SMILES	CNCCCN1c2ccccc2CCc2ccccc21
InChIKey	HCYAFALTSJYZDH-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	1
Rotatable bonds	4
Molecular weight (Da)	266.2

Database connections

ChEMBL_compound_ids ChEMBL_compound_ids PubChem DrugBank PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.15	8.15	8.15	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	7.64	7.64	7.64	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.86	5.86	5.86	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.23	8.23	8.23	Drug Central
β₂	ADRB2	Rat	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.32	5.64	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.00	5.06	5.19	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.28	8.28	8.28	Drug Central
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	6.97	6.97	6.97	PDSP Ki database
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	8.16	8.16	8.16	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	6.80	6.80	6.80	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.17	8.17	8.17	Drug Central
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	6.13	6.37	6.61	PDSP Ki database
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	6.13	6.13	6.13	PDSP Ki database
5-HT₇	5HT7R	Rat	5-Hydroxytryptamine	A	pKi	6.00	6.00	6.00	PDSP Ki database
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	6.00	6.00	6.00	PDSP Ki database
D₁	DRD1	Human	Dopamine	A	pKi	5.26	5.26	5.26	PDSP Ki database
D₁	DRD1	Human	Dopamine	A	pKi	8.28	8.28	8.28	Drug Central
D₂	DRD2	Human	Dopamine	A	pKi	5.46	5.63	5.81	PDSP Ki database
D₂	DRD2	Human	Dopamine	A	pKi	8.25	8.25	8.25	Drug Central

Showing 1 to 20 of 34 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	6.89	8.24	9.60	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	8.02	8.02	8.02	Drug Central
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pEC50	8.19	8.19	8.19	Drug Central
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pEC50	8.19	8.19	8.19	Drug Central
H₁	HRH1	Rat	Histamine	A	pIC50	9.10	9.10	9.10	ChEMBL
H₁	HRH1	Rat	Histamine	A	pIC50	8.04	8.04	8.04	Drug Central
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	5.55	6.03	6.50	ChEMBL
NPS	NPSR1	Human	Neuropeptide S	A	Potency	4.90	4.90	4.90	ChEMBL

Showing 1 to 8 of 8 entries

DESIPRAMINE

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 0

Phase II 6

Phase III 3

Phase IV 1

Database connections

ChEMBL_compound_ids ChEMBL_compound_ids PubChem DrugBank PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease

Gene	Protein	Receptor family	Ligand type	Class	Name	Phase	ICD11	ATC	Association score

5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Alcohol dependence, unspecified	3	6C40.2Z		0.268
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Cocaine dependence, unspecified	2	6C45.2Z		0.460
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Depressive disorders, unspecified	4	6A7Z		0.607
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Gastro-oesophageal reflux disease, unspecified	3	DA22.Z		0.013
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Obstructive sleep apnoea	2	7A41		0.050
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Pain, unspecified	2	MG3Z		0.545
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Rett syndrome	2	LD90.4		0.259
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Single episode depressive disorder, severe, without psychotic symptoms	2	6A70.3		0.632

Showing 1 to 8 of 8 entries