CHEMBL597601


SMILES Clc1ccc(-n2cc(CN3CCN(c4ccccc4)CC3)cn2)cc1
InChIKey MHJWMIITIMUUKU-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 4
Molecular weight (Da) 352.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α2A ADA2A Rat Adrenoceptors A pKi 5.6 5.6 5.6 ChEMBL
α1B ADA1B Rat Adrenoceptors A pKi 5.52 5.55 5.58 ChEMBL
D2 DRD2 Rat Dopamine A pKi 6.41 6.42 6.42 ChEMBL
D4 DRD4 Human Dopamine A pKi 6.75 6.76 6.77 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 6.66 6.8 7.05 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.06 5.06 5.07 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 7.05 7.05 7.05 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database