TEFLUDAZINE


SMILES OCCN1CCN([C@@H]2C[C@@H](c3ccc(F)cc3)c3ccc(C(F)(F)F)cc32)CC1
InChIKey JSBWGXQXCRYYTG-PZJWPPBQSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 4
Molecular weight (Da) 408.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D2 DRD2 Rat Dopamine A pKi 7.8 7.8 7.8 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 9.15 9.34 9.52 PDSP Ki database
D3 DRD3 Human Dopamine A pKi 8.77 9.0 9.22 PDSP Ki database
D4 DRD4 Human Dopamine A pKi 8.35 8.35 8.35 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D1 DRD1 Rat Dopamine A pIC50 7.72 7.72 7.72 ChEMBL
D2 DRD2 Rat Dopamine A pIC50 7.8 7.87 8.0 ChEMBL