BAY-294


SMILES CNCc1ccccc1-c1csc([C@H](C)Nc2nc(C)nc3cc(OC)c(OC)cc23)c1
InChIKey WEGLOYDTDILXDA-HNNXBMFYSA-N

Chemical properties

Hydrogen bond acceptors None
Hydrogen bond donors None
Rotatable bonds None
Molecular weight (Da)

Drug properties

Molecular type Na
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 5.98 5.98 5.98 ChEMBL
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 5.75 5.75 5.75 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 7.03 7.03 7.03 ChEMBL
α1B ADA1B Human Adrenoceptors A pKi 7.02 7.02 7.02 ChEMBL
α2B ADA2B Human Adrenoceptors A pKi 6.07 6.07 6.07 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 7.02 7.02 7.02 ChEMBL
H4 HRH4 Human Histamine A pKi 5.72 5.72 5.72 ChEMBL
H2 HRH2 Human Histamine A pKi 7.67 7.67 7.67 ChEMBL
α1D ADA1D Human Adrenoceptors A pKi 6.4 6.4 6.4 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 6.28 6.28 6.28 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 6.16 6.16 6.16 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 6.89 6.89 6.89 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 6.52 6.52 6.52 ChEMBL
H1 HRH1 Human Histamine A pKi 5.87 5.87 5.87 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 7.13 7.13 7.13 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 5.83 5.83 5.83 ChEMBL
D1 DRD1 Human Dopamine A pKi 6.14 6.14 6.14 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 6.21 6.21 6.21 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.15 6.15 6.15 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.41 6.41 6.41 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.16 7.16 7.16 ChEMBL
D3 DRD3 Human Dopamine A pKi 6.06 6.06 6.06 ChEMBL
κ OPRK Human Opioid A pKi 6.08 6.08 6.08 ChEMBL
μ OPRM Human Opioid A pKi 6.07 6.07 6.07 ChEMBL
D2 DRD2 Human Dopamine A pKi 5.63 5.63 5.63 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database