GproteinDb

JNJ16259685

Agent/drug
Bioactivity

JNJ16259685

SMILES	COC1CCC(C(=O)c2ccc3nc4c(cc3c2)CCCO4)CC1
InChIKey	QOTAQTRFJWLFCR-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	0
Rotatable bonds	3
Molecular weight (Da)	325.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids ChEMBL_compound_ids GPCRdb
Ligand site mutations	mGlu₁

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

mGlu₁	GRM1	Human	Metabotropic glutamate	C	pKi	9.47	9.47	9.47	ChEMBL

Showing 1 to 1 of 1 entry

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

mGlu₁	GRM1	Human	Metabotropic glutamate	C	pIC50	8.90	8.90	8.90	Guide to Pharmacology
mGlu₁	GRM1	Rat	Metabotropic glutamate	C	pIC50	7.35	7.93	8.52	ChEMBL
mGlu₁	GRM1	Human	Metabotropic glutamate	C	pIC50	6.97	8.38	9.26	ChEMBL

Showing 1 to 3 of 3 entries

JNJ16259685

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids ChEMBL_compound_ids GPCRdb
Ligand site mutations	mGlu₁

Compound is not listed as a drug.