BROMPERIDOL


SMILES C1CN(CCC1(C2=CC=C(C=C2)Br)O)CCCC(=O)C3=CC=C(C=C3)F
InChIKey RKLNONIVDFXQRX-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 6
Molecular weight (Da) 419.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D1 DRD1 Bovine Dopamine A pKi 6.22 6.22 6.22 PDSP Ki database
D2 DRD2 Bovine Dopamine A pKi 8.85 8.85 8.85 PDSP Ki database
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 5.15 5.15 5.15 PDSP Ki database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 5.12 5.12 5.12 PDSP Ki database
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 5.74 5.74 5.74 PDSP Ki database
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 5.77 5.77 5.77 PDSP Ki database
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 5.32 5.32 5.32 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 8.68 8.84 9.0 PDSP Ki database
D3 DRD3 Human Dopamine A pKi 8.64 9.17 9.7 PDSP Ki database
D4 DRD4 Human Dopamine A pKi 7.32 7.32 7.32 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.6 5.6 5.6 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.39 7.39 7.39 PDSP Ki database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 5.3 5.3 5.3 PDSP Ki database
M3 ACM3 Rat Acetylcholine (muscarinic) A pKi 5.15 5.15 5.15 PDSP Ki database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 8.29 8.29 8.29 Drug Central
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 8.24 8.24 8.24 Drug Central
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 8.29 8.29 8.29 Drug Central
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 8.24 8.24 8.24 Drug Central
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 8.27 8.27 8.27 Drug Central
α1A ADA1A Human Adrenoceptors A pKi 8.15 8.15 8.15 Drug Central
D1 DRD1 Human Dopamine A pKi 8.15 8.15 8.15 Drug Central
D2 DRD2 Human Dopamine A pKi 8.07 8.07 8.07 Drug Central
D3 DRD3 Human Dopamine A pKi 8.12 8.12 8.12 Drug Central
D4 DRD4 Human Dopamine A pKi 8.11 8.11 8.11 Drug Central
H1 HRH1 Human Histamine A pKi 8.21 8.21 8.21 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database