GproteinDb

JNJ-40411813

Agent/drug
Bioactivity

JNJ-40411813

SMILES	CCCCn1ccc(N2CCC(c3ccccc3)CC2)c(Cl)c1=O
InChIKey	HYOGJHCDLQSAHX-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	0
Rotatable bonds	5
Molecular weight (Da)	344.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank GPCRdb
Structure pdb	8JD3 8JD5 7E9G

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

mGlu₂	GRM2	Human	Metabotropic glutamate	C	pKi	6.75	6.75	6.75	ChEMBL

Showing 1 to 1 of 1 entry

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

mGlu₂	GRM2	Human	Metabotropic glutamate	C	pIC50	7.17	7.17	7.17	ChEMBL
mGlu₂	GRM2	Human	Metabotropic glutamate	C	pEC50	5.59	6.39	7.19	ChEMBL
mGlu₂	GRM2	Human	Metabotropic glutamate	C	pEC50	6.83	6.83	6.83	Guide to Pharmacology

Showing 1 to 3 of 3 entries

JNJ-40411813

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank GPCRdb
Structure pdb	8JD3 8JD5 7E9G

Compound is not listed as a drug.