RILAPINE


SMILES CN1CCN(CC1)C2=CC3=C(C=CC(=C3)Cl)C(=CC#N)C4=CC=CC=C42
InChIKey UJCYUJOQBXHJFH-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 1
Molecular weight (Da) 361.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 8.16 8.16 8.16 PDSP Ki database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 8.55 8.55 8.55 PDSP Ki database
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 9.1 9.1 9.1 PDSP Ki database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 7.6 7.63 7.64 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 7.4 7.4 7.4 PDSP Ki database
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 5.85 5.85 5.85 PDSP Ki database
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 6.0 6.0 6.0 PDSP Ki database
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 5.96 5.96 5.96 PDSP Ki database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 6.72 6.72 6.72 PDSP Ki database
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 6.33 6.33 6.33 PDSP Ki database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 7.77 7.77 7.77 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database