L-657,743


SMILES CN1CCC2(CCN3CCC4=C(C3C2)OC5=CC=CC=C45)N(C1=O)C
InChIKey JRDUBBHIPPPSLP-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 0
Molecular weight (Da) 339.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α2A ADA2A Human Adrenoceptors A pKi 9.38 9.38 9.38 PDSP Ki database
α2C ADA2C Human Adrenoceptors A pKi 10.52 10.52 10.52 PDSP Ki database
α2B ADA2B Rat Adrenoceptors A pKi 9.59 9.59 9.59 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database