ENPROSTIL


SMILES COC(=O)CCC=C=CCC1C(C(CC1=O)O)C=CC(COC2=CC=CC=C2)O
InChIKey PTOJVMZPWPAXER-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 10
Molecular weight (Da) 400.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
FP PF2R Bovine Prostanoid A pKi 6.0 6.0 6.0 PDSP Ki database
EP3 PE2R3 Bovine Prostanoid A pKi 7.6 7.76 7.92 PDSP Ki database
EP1 PE2R1 Human Prostanoid A pKi 7.09 7.09 7.09 PDSP Ki database
EP4 PE2R4 Human Prostanoid A pKi 5.0 5.0 5.0 PDSP Ki database
DP1 PD2R Human Prostanoid A pKi 5.0 5.0 5.0 PDSP Ki database
EP3 PE2R3 Human Prostanoid A pKi 7.92 7.92 7.92 PDSP Ki database
FP PF2R Human Prostanoid A pKi 7.06 7.06 7.06 PDSP Ki database
IP PI2R Human Prostanoid A pKi 5.0 5.0 5.0 PDSP Ki database
EP4 PE2R4 Human Prostanoid A pKi 8.13 8.13 8.13 Drug Central
FP PF2R Human Prostanoid A pKi 8.15 8.15 8.15 Drug Central
EP3 PE2R3 Rat Prostanoid A pKi 8.15 8.15 8.15 Drug Central
EP1 PE2R1 Rat Prostanoid A pKi 8.17 8.17 8.17 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
EP1 PE2R1 Human Prostanoid A pEC50 8.12 8.12 8.12 Drug Central
EP3 PE2R3 Human Prostanoid A pEC50 8.1 8.1 8.1 Drug Central