GproteinDb

ketanserin

Agent/drug
Bioactivity

ketanserin

SMILES	O=C(c1ccc(F)cc1)C1CCN(CCn2c(=O)[nH]c3ccccc3c2=O)CC1
InChIKey	FPCCSQOGAWCVBH-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	5
Hydrogen bond donors	1
Rotatable bonds	5
Molecular weight (Da)	395.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids Drug Central DrugBank Guide To Pharmacology PubChem GPCRdb
Ligand site mutations	α_1B 5-HT_1D 5-HT_2A 5-HT_2C

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.20	8.20	8.20	Guide to Pharmacology
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.09	8.09	8.09	Drug Central
α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	8.00	8.00	8.00	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.20	8.20	8.20	Guide to Pharmacology
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.09	8.09	8.09	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	7.80	7.80	7.80	Guide to Pharmacology
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.11	8.11	8.11	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.43	6.43	6.43	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.70	6.70	6.70	PDSP Ki database
α_2B	ADA2B	Rat	Adrenoceptors	A	pKi	6.65	6.65	6.65	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.17	8.17	8.17	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.80	6.80	6.80	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	Guide to Pharmacology
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	5.71	5.72	5.74	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKd	6.10	6.10	6.10	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.33	5.71	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.00	5.43	5.98	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.30	8.30	8.30	Drug Central
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	8.24	8.24	8.24	Drug Central
5-HT_1B	5HT1B	Mouse	5-Hydroxytryptamine	A	pKi	8.30	8.30	8.30	Guide to Pharmacology

Showing 1 to 20 of 103 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pIC50	5.20	5.30	5.40	Guide to Pharmacology
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pIC50	8.28	8.28	8.28	Drug Central
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pIC50	5.19	5.19	5.19	ChEMBL
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pIC50	8.18	8.18	8.18	Drug Central
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pIC50	6.57	6.58	6.58	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	7.08	8.33	9.46	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pEC50	8.98	8.98	8.98	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	6.54	6.54	6.54	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	8.57	8.57	8.57	ChEMBL
A₃	AA3R	Human	Adenosine	A	pIC50	8.07	8.07	8.07	Drug Central
D₂	DRD2	Rat	Dopamine	A	pIC50	5.75	5.75	5.75	ChEMBL
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	4.80	4.80	4.80	ChEMBL
NPS	NPSR1	Human	Neuropeptide S	A	Potency	5.80	5.80	5.80	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	4.50	4.50	4.50	ChEMBL

Showing 1 to 14 of 14 entries

ketanserin

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 1

Phase II 0

Phase III 1

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids Drug Central DrugBank Guide To Pharmacology PubChem GPCRdb
Ligand site mutations	α_1B 5-HT_1D 5-HT_2A 5-HT_2C

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Acute kidney failure, stage unspecified	GB60.Z	C02K	0.007	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Essential hypertension, unspecified	BA00.Z	C02K	0.002	4	Yes

Showing 1 to 2 of 2 entries