SORAFENIB


SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1
InChIKey MLDQJTXFUGDVEO-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 5
Molecular weight (Da) 464.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 5.48 5.48 5.48 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 5.15 5.15 5.15 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 5.21 5.21 5.21 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 7.25 7.25 7.25 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.93 5.93 5.93 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.23 8.23 8.23 Drug Central
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.24 8.24 8.24 Drug Central
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.14 8.14 8.14 Drug Central
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.2 8.2 8.2 Drug Central
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 8.26 8.26 8.26 Drug Central
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 8.28 8.28 8.28 Drug Central
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 8.29 8.29 8.29 Drug Central
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 5.71 5.71 5.71 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.38 6.38 6.38 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
NTS1 NTR1 Human Neurotensin A pEC50 4.84 4.84 4.84 ChEMBL
MC4 MC4R Human Melanocortin A pIC50 5.35 5.35 5.35 ChEMBL